| http://purl.uniprot.org/citations/23063329 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23063329 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23063329 | http://www.w3.org/2000/01/rdf-schema#comment | "Celiac disease is a human leukocyte antigen (HLA)-DQ2-and/or DQ8-associated T cell-mediated disorder that is induced by dietary gluten. Although it is established how gluten peptides bind HLA-DQ8 and HLA-DQ2, it is unclear how such peptide-HLA complexes are engaged by the T cell receptor (TCR), a recognition event that triggers disease pathology. We show that biased TCR usage (TRBV9(∗)01) underpins the recognition of HLA-DQ8-α-I-gliadin. The structure of a prototypical TRBV9(∗)01-TCR-HLA-DQ8-α-I-gliadin complex shows that the TCR docks centrally above HLA-DQ8-α-I-gliadin, in which all complementarity-determining region-β (CDRβ) loops interact with the gliadin peptide. Mutagenesis at the TRBV9(∗)01-TCR-HLA-DQ8-α-I-gliadin interface provides an energetic basis for the Vβ bias. Moreover, CDR3 diversity accounts for TRBV9(∗)01(+) TCRs exhibiting differing reactivities toward the gliadin epitopes at various deamidation states. Accordingly, biased TCR usage is an important factor in the pathogenesis of DQ8-mediated celiac disease."xsd:string |
| http://purl.uniprot.org/citations/23063329 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2012.07.013"xsd:string |
| http://purl.uniprot.org/citations/23063329 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2012.07.013"xsd:string |
| http://purl.uniprot.org/citations/23063329 | http://purl.uniprot.org/core/author | "Thompson A."xsd:string |
| http://purl.uniprot.org/citations/23063329 | http://purl.uniprot.org/core/author | "Thompson A."xsd:string |
| http://purl.uniprot.org/citations/23063329 | http://purl.uniprot.org/core/author | "Theodossis A."xsd:string |
| http://purl.uniprot.org/citations/23063329 | http://purl.uniprot.org/core/author | "Theodossis A."xsd:string |
| http://purl.uniprot.org/citations/23063329 | http://purl.uniprot.org/core/author | "Scally S.W."xsd:string |
| http://purl.uniprot.org/citations/23063329 | http://purl.uniprot.org/core/author | "Scally S.W."xsd:string |
| http://purl.uniprot.org/citations/23063329 | http://purl.uniprot.org/core/author | "Petersen J."xsd:string |
| http://purl.uniprot.org/citations/23063329 | http://purl.uniprot.org/core/author | "Petersen J."xsd:string |
| http://purl.uniprot.org/citations/23063329 | http://purl.uniprot.org/core/author | "Purcell A.W."xsd:string |
| http://purl.uniprot.org/citations/23063329 | http://purl.uniprot.org/core/author | "Purcell A.W."xsd:string |
| http://purl.uniprot.org/citations/23063329 | http://purl.uniprot.org/core/author | "Rossjohn J."xsd:string |
| http://purl.uniprot.org/citations/23063329 | http://purl.uniprot.org/core/author | "Rossjohn J."xsd:string |
| http://purl.uniprot.org/citations/23063329 | http://purl.uniprot.org/core/author | "Beddoe T."xsd:string |
| http://purl.uniprot.org/citations/23063329 | http://purl.uniprot.org/core/author | "Beddoe T."xsd:string |
| http://purl.uniprot.org/citations/23063329 | http://purl.uniprot.org/core/author | "McCluskey J."xsd:string |
| http://purl.uniprot.org/citations/23063329 | http://purl.uniprot.org/core/author | "McCluskey J."xsd:string |
| http://purl.uniprot.org/citations/23063329 | http://purl.uniprot.org/core/author | "Reid H.H."xsd:string |
| http://purl.uniprot.org/citations/23063329 | http://purl.uniprot.org/core/author | "Reid H.H."xsd:string |
| http://purl.uniprot.org/citations/23063329 | http://purl.uniprot.org/core/author | "Anderson R.P."xsd:string |
| http://purl.uniprot.org/citations/23063329 | http://purl.uniprot.org/core/author | "Anderson R.P."xsd:string |