| http://purl.uniprot.org/citations/23063333 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23063333 | http://www.w3.org/2000/01/rdf-schema#comment | "Innate lymphoid cells (ILCs) reside at mucosal surfaces and control immunity to intestinal infections. Type 2 innate lymphoid cells (ILC2s) produce cytokines such as IL-5 and IL-13, are required for immune defense against helminth infections, and are involved in the pathogenesis of airway hyperreactivity. Here, we have investigated the role of the transcription factor GATA-3 for ILC2 differentiation and maintenance. We showed that ILC2s and their lineage-specified bone marrow precursors (ILC2Ps), as identified here, were characterized by continuous high expression of GATA-3. Analysis of mice with temporary deletion of GATA-3 in all ILCs showed that GATA-3 was required for the differentiation and maintenance of ILC2s but not for RORγt(+) ILCs. Thus, our data demonstrate that GATA-3 is essential for ILC2 fate decisions and reveal similarities between the transcriptional programs controlling ILC and T helper cell fates."xsd:string |
| http://purl.uniprot.org/citations/23063333 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2012.06.020"xsd:string |
| http://purl.uniprot.org/citations/23063333 | http://purl.uniprot.org/core/author | "Pfeifer D."xsd:string |
| http://purl.uniprot.org/citations/23063333 | http://purl.uniprot.org/core/author | "Busslinger M."xsd:string |
| http://purl.uniprot.org/citations/23063333 | http://purl.uniprot.org/core/author | "Diefenbach A."xsd:string |
| http://purl.uniprot.org/citations/23063333 | http://purl.uniprot.org/core/author | "Hoyler T."xsd:string |
| http://purl.uniprot.org/citations/23063333 | http://purl.uniprot.org/core/author | "Voehringer D."xsd:string |
| http://purl.uniprot.org/citations/23063333 | http://purl.uniprot.org/core/author | "Souabni A."xsd:string |
| http://purl.uniprot.org/citations/23063333 | http://purl.uniprot.org/core/author | "Rawlins E.L."xsd:string |
| http://purl.uniprot.org/citations/23063333 | http://purl.uniprot.org/core/author | "Klose C.S."xsd:string |
| http://purl.uniprot.org/citations/23063333 | http://purl.uniprot.org/core/author | "Turqueti-Neves A."xsd:string |
| http://purl.uniprot.org/citations/23063333 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23063333 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/23063333 | http://purl.uniprot.org/core/pages | "634-648"xsd:string |
| http://purl.uniprot.org/citations/23063333 | http://purl.uniprot.org/core/title | "The transcription factor GATA-3 controls cell fate and maintenance of type 2 innate lymphoid cells."xsd:string |
| http://purl.uniprot.org/citations/23063333 | http://purl.uniprot.org/core/volume | "37"xsd:string |
| http://purl.uniprot.org/citations/23063333 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23063333 |
| http://purl.uniprot.org/citations/23063333 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23063333 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1L1-mappedCitation-23063333 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23063333 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGP1-mappedCitation-23063333 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23063333 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGZ6-mappedCitation-23063333 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23063333 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J0F5-mappedCitation-23063333 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23063333 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JF13-mappedCitation-23063333 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23063333 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GQZ2-mappedCitation-23063333 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23063333 |