| http://purl.uniprot.org/citations/23063654 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23063654 | http://www.w3.org/2000/01/rdf-schema#comment | "RNase III Drosha initiates microRNA (miRNA) maturation by cleaving a primary miRNA transcript and releasing a pre-miRNA with a 2 nt 3' overhang. Dicer recognizes the 2 nt 3' overhang structure to selectively process pre-miRNAs. Here, we find that, unlike prototypic pre-miRNAs (group I), group II pre-miRNAs acquire a shorter (1 nt) 3' overhang from Drosha processing and therefore require a 3'-end mono-uridylation for Dicer processing. The majority of let-7 and miR-105 belong to group II. We identify TUT7/ZCCHC6, TUT4/ZCCHC11, and TUT2/PAPD4/GLD2 as the terminal uridylyl transferases responsible for pre-miRNA mono-uridylation. The TUTs act specifically on dsRNAs with a 1 nt 3' overhang, thereby creating a 2 nt 3' overhang. Depletion of TUTs reduces let-7 levels and disrupts let-7 function. Although the let-7 suppressor, Lin28, induces inhibitory oligo-uridylation in embryonic stem cells, mono-uridylation occurs in somatic cells lacking Lin28 to promote let-7 biogenesis. Our study reveals functional duality of uridylation and introduces TUT7/4/2 as components of the miRNA biogenesis pathway."xsd:string |
| http://purl.uniprot.org/citations/23063654 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2012.09.022"xsd:string |
| http://purl.uniprot.org/citations/23063654 | http://purl.uniprot.org/core/author | "Chang H."xsd:string |
| http://purl.uniprot.org/citations/23063654 | http://purl.uniprot.org/core/author | "Heo I."xsd:string |
| http://purl.uniprot.org/citations/23063654 | http://purl.uniprot.org/core/author | "Ha M."xsd:string |
| http://purl.uniprot.org/citations/23063654 | http://purl.uniprot.org/core/author | "Lim J."xsd:string |
| http://purl.uniprot.org/citations/23063654 | http://purl.uniprot.org/core/author | "Kim V.N."xsd:string |
| http://purl.uniprot.org/citations/23063654 | http://purl.uniprot.org/core/author | "Yoon M.J."xsd:string |
| http://purl.uniprot.org/citations/23063654 | http://purl.uniprot.org/core/author | "Park J.E."xsd:string |
| http://purl.uniprot.org/citations/23063654 | http://purl.uniprot.org/core/author | "Kwon S.C."xsd:string |
| http://purl.uniprot.org/citations/23063654 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23063654 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/23063654 | http://purl.uniprot.org/core/pages | "521-532"xsd:string |
| http://purl.uniprot.org/citations/23063654 | http://purl.uniprot.org/core/title | "Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs."xsd:string |
| http://purl.uniprot.org/citations/23063654 | http://purl.uniprot.org/core/volume | "151"xsd:string |
| http://purl.uniprot.org/citations/23063654 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23063654 |
| http://purl.uniprot.org/citations/23063654 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23063654 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DFM7-mappedCitation-23063654 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23063654 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DFW3-mappedCitation-23063654 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23063654 |
| http://purl.uniprot.org/uniprot/#_D6RAF2-mappedCitation-23063654 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23063654 |
| http://purl.uniprot.org/uniprot/#_Q5VYS8-mappedCitation-23063654 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23063654 |
| http://purl.uniprot.org/uniprot/#_Q5TAX3-mappedCitation-23063654 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23063654 |
| http://purl.uniprot.org/uniprot/#_Q6PIY7-mappedCitation-23063654 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23063654 |
| http://purl.uniprot.org/uniprot/#_Q96KX5-mappedCitation-23063654 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23063654 |