| http://purl.uniprot.org/citations/23064464 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23064464 | http://www.w3.org/2000/01/rdf-schema#comment | "Anaplastic large cell lymphoma (ALCL) is an aggressive non-Hodgkin's lymphoma found in children and young adults. ALCLs frequently carry a chromosomal translocation that results in expression of the oncoprotein nucleophosmin-anaplastic lymphoma kinase (NPM-ALK). The key molecular downstream events required for NPM-ALK-triggered lymphoma growth have been only partly unveiled. Here we show that the activator protein 1 family members JUN and JUNB promote lymphoma development and tumor dissemination through transcriptional regulation of platelet-derived growth factor receptor-β (PDGFRB) in a mouse model of NPM-ALK-triggered lymphomagenesis. Therapeutic inhibition of PDGFRB markedly prolonged survival of NPM-ALK transgenic mice and increased the efficacy of an ALK-specific inhibitor in transplanted NPM-ALK tumors. Notably, inhibition of PDGFRA and PDGFRB in a patient with refractory late-stage NPM-ALK(+) ALCL resulted in rapid, complete and sustained remission. Together, our data identify PDGFRB as a previously unknown JUN and JUNB target that could be a highly effective therapy for ALCL."xsd:string |
| http://purl.uniprot.org/citations/23064464 | http://purl.org/dc/terms/identifier | "doi:10.1038/nm.2966"xsd:string |
| http://purl.uniprot.org/citations/23064464 | http://purl.uniprot.org/core/author | "Knapp S."xsd:string |
| http://purl.uniprot.org/citations/23064464 | http://purl.uniprot.org/core/author | "Cheng M."xsd:string |
| http://purl.uniprot.org/citations/23064464 | http://purl.uniprot.org/core/author | "Penninger J.M."xsd:string |
| http://purl.uniprot.org/citations/23064464 | http://purl.uniprot.org/core/author | "Eferl R."xsd:string |
| http://purl.uniprot.org/citations/23064464 | http://purl.uniprot.org/core/author | "Kenner L."xsd:string |
| http://purl.uniprot.org/citations/23064464 | http://purl.uniprot.org/core/author | "Merkel O."xsd:string |
| http://purl.uniprot.org/citations/23064464 | http://purl.uniprot.org/core/author | "Moriggl R."xsd:string |
| http://purl.uniprot.org/citations/23064464 | http://purl.uniprot.org/core/author | "Schlederer M."xsd:string |
| http://purl.uniprot.org/citations/23064464 | http://purl.uniprot.org/core/author | "Valent P."xsd:string |
| http://purl.uniprot.org/citations/23064464 | http://purl.uniprot.org/core/author | "Jaeger U."xsd:string |
| http://purl.uniprot.org/citations/23064464 | http://purl.uniprot.org/core/author | "Kollmann K."xsd:string |
| http://purl.uniprot.org/citations/23064464 | http://purl.uniprot.org/core/author | "Inghirami G."xsd:string |
| http://purl.uniprot.org/citations/23064464 | http://purl.uniprot.org/core/author | "Dolznig H."xsd:string |
| http://purl.uniprot.org/citations/23064464 | http://purl.uniprot.org/core/author | "Piva R."xsd:string |
| http://purl.uniprot.org/citations/23064464 | http://purl.uniprot.org/core/author | "Pileri S."xsd:string |
| http://purl.uniprot.org/citations/23064464 | http://purl.uniprot.org/core/author | "Sexl V."xsd:string |
| http://purl.uniprot.org/citations/23064464 | http://purl.uniprot.org/core/author | "Vesely P.W."xsd:string |
| http://purl.uniprot.org/citations/23064464 | http://purl.uniprot.org/core/author | "Schiefer A.I."xsd:string |
| http://purl.uniprot.org/citations/23064464 | http://purl.uniprot.org/core/author | "Hofler G."xsd:string |
| http://purl.uniprot.org/citations/23064464 | http://purl.uniprot.org/core/author | "Medico E."xsd:string |
| http://purl.uniprot.org/citations/23064464 | http://purl.uniprot.org/core/author | "Shehata M."xsd:string |
| http://purl.uniprot.org/citations/23064464 | http://purl.uniprot.org/core/author | "Simonitsch-Klupp I."xsd:string |