| http://purl.uniprot.org/citations/23066153 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23066153 | http://www.w3.org/2000/01/rdf-schema#comment | "CYLD was originally identified as a tumor suppressor gene mutated in familial cylindromatosis, an autosomal dominant predisposition to multiple benign neoplasms of the skin known as cylindromas. The CYLD protein is a deubiquitinating enzyme that acts as a negative regulator of NF-κB and JNK signaling through its interaction with NEMO and TNFR-associated factor 2. We have previously described a novel mouse strain that expresses solely and excessively a naturally occurring splice variant of CYLD (CYLD(ex7/8)). In this study, we demonstrate that CYLD plays a critical role in Treg development and function. T cells of CYLD(ex7/8) mice had a hyperactive phenotype manifested by increased production of inflammatory cytokines and constitutive activation of the NF-κB pathway. Furthermore, the amount of Foxp3(+) regulatory T cells in these mice was markedly enhanced in thymus and peripheral organs. Importantly, these regulatory T cells displayed decreased expression levels of CD25 and CTLA-4 associated with impaired suppressive capacity. Hence, our data emphasize an essential role of CYLD in maintaining T cell homeostasis as well as normal T regulatory cell function, thereby controlling abnormal T cell responses."xsd:string |
| http://purl.uniprot.org/citations/23066153 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1201993"xsd:string |
| http://purl.uniprot.org/citations/23066153 | http://purl.uniprot.org/core/author | "Nikolaev A."xsd:string |
| http://purl.uniprot.org/citations/23066153 | http://purl.uniprot.org/core/author | "Hahn M."xsd:string |
| http://purl.uniprot.org/citations/23066153 | http://purl.uniprot.org/core/author | "Waisman A."xsd:string |
| http://purl.uniprot.org/citations/23066153 | http://purl.uniprot.org/core/author | "Neurath M.F."xsd:string |
| http://purl.uniprot.org/citations/23066153 | http://purl.uniprot.org/core/author | "Weigmann B."xsd:string |
| http://purl.uniprot.org/citations/23066153 | http://purl.uniprot.org/core/author | "Wunderlich T.F."xsd:string |
| http://purl.uniprot.org/citations/23066153 | http://purl.uniprot.org/core/author | "Kalt B."xsd:string |
| http://purl.uniprot.org/citations/23066153 | http://purl.uniprot.org/core/author | "Hovelmeyer N."xsd:string |
| http://purl.uniprot.org/citations/23066153 | http://purl.uniprot.org/core/author | "Reissig S."xsd:string |
| http://purl.uniprot.org/citations/23066153 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23066153 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/23066153 | http://purl.uniprot.org/core/pages | "4770-4776"xsd:string |
| http://purl.uniprot.org/citations/23066153 | http://purl.uniprot.org/core/title | "The tumor suppressor CYLD controls the function of murine regulatory T cells."xsd:string |
| http://purl.uniprot.org/citations/23066153 | http://purl.uniprot.org/core/volume | "189"xsd:string |
| http://purl.uniprot.org/citations/23066153 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23066153 |
| http://purl.uniprot.org/citations/23066153 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23066153 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GSE5-mappedCitation-23066153 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23066153 |
| http://purl.uniprot.org/uniprot/#_Q3UY73-mappedCitation-23066153 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23066153 |
| http://purl.uniprot.org/uniprot/#_Q3V028-mappedCitation-23066153 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23066153 |
| http://purl.uniprot.org/uniprot/#_Q3TJI3-mappedCitation-23066153 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23066153 |
| http://purl.uniprot.org/uniprot/#_Q80TQ2-mappedCitation-23066153 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23066153 |
| http://purl.uniprot.org/uniprot/#_Z4YJJ5-mappedCitation-23066153 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23066153 |