| http://purl.uniprot.org/citations/23067879 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23067879 | http://www.w3.org/2000/01/rdf-schema#comment | "Moderate reductions in synaptic γ-aminobutyric acid(A) receptors (GABA(A)Rs) have been associated with an enhanced defensive behavioral reactivity to mild threat, sensitive to diazepam. We here tested whether a deficit in α2 subunit-containing GABAergic synapses is sufficient to cause this anxiety-related phenotype and to prevent its attenuation by the benzodiazepine. Wild type (α2+/+), heterozygous (α2+/-) and homozygous (α2-/-) knock-out littermates were tested in the free-choice exploratory (FCE) and the light/dark choice (LDC) paradigms. α2-/- mice, double mutant α1H101Rα2-/- and α3H126Rα2-/-mice, which combine a lack of α2-GABA(A)Rs with point-mutated diazepam-insensitive either α1H101R or α3H126R-GABA(A)Rs, and double point-mutated α1H101Rα2H101R and α1H101Rα3H126R mice were used to uncover the GABA(A)R subtype(s) mediating the drug effects. Data show that in the FCE, α2-/-mice exhibited more retractions (i.e. risk assessment) and longer latencies to first occurrence into the novel compartment and less transitions and time spent inside it in comparison to α2+/- and α2+/+ mice. In the LDC, α2-/-mice visited and spent less time in the lit box and stayed longer in the tunnel than the other two groups. Minor differences were found between α2+/- and α2+/+ mice in the two paradigms. Diazepam (1.5mg/kg per os) normalized retractions and latencies in the FCE in α2-/- and α3H126Rα2-/-mice, but not in α1H101Rα2-/-mice. The same drug treatment failed to attenuate behavioral aversion in both paradigms in all mutants with impaired α2-GABA(A)R function. These results reveal α2-containing GABA(A)Rs as key molecular determinants in the regulation of anxiety-related responses elicited by exposure to relative novelty and mild threat. In the absence of these receptors, diazepam through activation of α1-GABA(A)Rs remains effective in reducing risk assessment, but not behavioral aversion."xsd:string |
| http://purl.uniprot.org/citations/23067879 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.pbb.2012.10.004"xsd:string |
| http://purl.uniprot.org/citations/23067879 | http://purl.uniprot.org/core/author | "Koester C."xsd:string |
| http://purl.uniprot.org/citations/23067879 | http://purl.uniprot.org/core/author | "Fritschy J.M."xsd:string |
| http://purl.uniprot.org/citations/23067879 | http://purl.uniprot.org/core/author | "Haenggi T."xsd:string |
| http://purl.uniprot.org/citations/23067879 | http://purl.uniprot.org/core/author | "Rudolph U."xsd:string |
| http://purl.uniprot.org/citations/23067879 | http://purl.uniprot.org/core/author | "Crestani F."xsd:string |
| http://purl.uniprot.org/citations/23067879 | http://purl.uniprot.org/core/author | "Papilloud A."xsd:string |
| http://purl.uniprot.org/citations/23067879 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23067879 | http://purl.uniprot.org/core/name | "Pharmacol Biochem Behav"xsd:string |
| http://purl.uniprot.org/citations/23067879 | http://purl.uniprot.org/core/pages | "541-549"xsd:string |
| http://purl.uniprot.org/citations/23067879 | http://purl.uniprot.org/core/title | "Dissecting the role of diazepam-sensitive gamma-aminobutyric acid type A receptors in defensive behavioral reactivity to mild threat."xsd:string |
| http://purl.uniprot.org/citations/23067879 | http://purl.uniprot.org/core/volume | "103"xsd:string |
| http://purl.uniprot.org/citations/23067879 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23067879 |
| http://purl.uniprot.org/citations/23067879 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23067879 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGP5-mappedCitation-23067879 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23067879 |
| http://purl.uniprot.org/uniprot/#_A0A0H2UKB5-mappedCitation-23067879 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23067879 |
| http://purl.uniprot.org/uniprot/#_B1AVY2-mappedCitation-23067879 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23067879 |
| http://purl.uniprot.org/uniprot/#_P26048-mappedCitation-23067879 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23067879 |
| http://purl.uniprot.org/uniprot/#_P26049-mappedCitation-23067879 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23067879 |
| http://purl.uniprot.org/uniprot/#_Q544G1-mappedCitation-23067879 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23067879 |
| http://purl.uniprot.org/uniprot/#_Q8CAB3-mappedCitation-23067879 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23067879 |
| http://purl.uniprot.org/uniprot/Q8CAB3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23067879 |
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