| http://purl.uniprot.org/citations/23071286 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23071286 | http://www.w3.org/2000/01/rdf-schema#comment | "The pathology associated with Streptococcus pneumoniae meningitis results largely from activation of immune-associated pathways. We systematically investigated the production of IFN subtypes, as well as their influence on pathology, in a mouse model of S. pneumoniae meningitis. Despite the occurrence of a mixed IFN type I/II gene signature, no evidence for production or involvement of type I IFNs in disease progression was found. In contrast, type II IFN (IFN-γ) was strongly induced, and IFN-γ(-/-) mice were significantly protected from severe disease. Using intracellular cytokine staining and targeted cell-depletion approaches, NK cells were found to be the dominant source of IFN-γ. Furthermore, production of IFN-γ was found to be dependent upon ASC and IL-18, indicating that an ASC-dependent inflammasome pathway was responsible for mediating IFN-γ induction. The influence of IFN-γ gene deletion on a range of processes known to be involved in bacterial meningitis pathogenesis was examined. Although neutrophil numbers in the brain were similar in infected wild-type and IFN-γ(-/-) mice, both monocyte recruitment and CCL2 production were less in infected IFN-γ(-/-) mice compared with infected wild-type controls. Additionally, gene expression of NO synthase was strongly diminished in infected IFN-γ(-/-) mice compared with infected controls. Finally, bacterial clearance was enhanced in IFN-γ(-/-) mice, although the underlying mechanism remains unclear. Together, these data suggest that inflammasome-dependent IFN-γ contributes via multiple pathways to pathology during S. pneumoniae meningitis."xsd:string |
| http://purl.uniprot.org/citations/23071286 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1201687"xsd:string |
| http://purl.uniprot.org/citations/23071286 | http://purl.uniprot.org/core/author | "Mitchell A.J."xsd:string |
| http://purl.uniprot.org/citations/23071286 | http://purl.uniprot.org/core/author | "Yau B."xsd:string |
| http://purl.uniprot.org/citations/23071286 | http://purl.uniprot.org/core/author | "Jones C.A."xsd:string |
| http://purl.uniprot.org/citations/23071286 | http://purl.uniprot.org/core/author | "Hertzog P."xsd:string |
| http://purl.uniprot.org/citations/23071286 | http://purl.uniprot.org/core/author | "Weninger W."xsd:string |
| http://purl.uniprot.org/citations/23071286 | http://purl.uniprot.org/core/author | "Ball H.J."xsd:string |
| http://purl.uniprot.org/citations/23071286 | http://purl.uniprot.org/core/author | "Hunt N.H."xsd:string |
| http://purl.uniprot.org/citations/23071286 | http://purl.uniprot.org/core/author | "McQuillan J.A."xsd:string |
| http://purl.uniprot.org/citations/23071286 | http://purl.uniprot.org/core/author | "Leib S.L."xsd:string |
| http://purl.uniprot.org/citations/23071286 | http://purl.uniprot.org/core/author | "Abtin A."xsd:string |
| http://purl.uniprot.org/citations/23071286 | http://purl.uniprot.org/core/author | "Gerega S.K."xsd:string |
| http://purl.uniprot.org/citations/23071286 | http://purl.uniprot.org/core/author | "Too L.K."xsd:string |
| http://purl.uniprot.org/citations/23071286 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23071286 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/23071286 | http://purl.uniprot.org/core/pages | "4970-4980"xsd:string |
| http://purl.uniprot.org/citations/23071286 | http://purl.uniprot.org/core/title | "Inflammasome-dependent IFN-gamma drives pathogenesis in Streptococcus pneumoniae meningitis."xsd:string |
| http://purl.uniprot.org/citations/23071286 | http://purl.uniprot.org/core/volume | "189"xsd:string |
| http://purl.uniprot.org/citations/23071286 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23071286 |
| http://purl.uniprot.org/citations/23071286 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23071286 |
| http://purl.uniprot.org/uniprot/#_A0A1L1STF5-mappedCitation-23071286 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23071286 |
| http://purl.uniprot.org/uniprot/#_A0A7R8C347-mappedCitation-23071286 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23071286 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J090-mappedCitation-23071286 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23071286 |