| http://purl.uniprot.org/citations/23075394 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23075394 | http://www.w3.org/2000/01/rdf-schema#comment | "Homozygosity for a nonsense mutation in the fucosyltransferase 2 (FUT2) gene (rs601338G>A) leads to the absence of ABH blood groups (FUT2 non-secretor status) in body fluids. As the secretor status has been shown to be a major determinant for the gut microbial spectrum, assumed to be important in the gut immune homeostasis, we studied the association of rs601338-FUT2 with celiac disease (CelD) and inflammatory bowel disease (IBD) in the Finnish population. Rs601338 was genotyped in CelD (n = 909), dermatitis herpetiformis (DH) (n = 116), ulcerative colitis (UC) (n = 496) and Crohn's disease (CD) (n = 280) patients and healthy controls (n = 2738). CelD showed significant genotypic [P = 0.0074, odds ratio (OR): 1.28] and recessive (P = 0.015, OR: 1.28) association with the rs601338-AA genotype. This was also found in the combined CelD+DH dataset (genotype association: P = 0.0060, OR: 1.28; recessive association: P < 0.011, OR: 1.28). The A allele of rs601338 showed nominal association with dominant protection from UC (P = 0.044, OR: 0.82) and UC+CD (P = 0.035, OR: 0.84). The frequency of non-secretors (rs601338-GG) in controls, CelD, DH, UC and CD datasets was 14.7%, 18%, 18.1%, 14.3% and 16.1%, respectively. No association was evident in the DH or CD datasets alone. In conclusion, FUT2 non-secretor status is associated with CelD susceptibility and FUT2 secretor status may also play a role in IBD in the Finnish population."xsd:string |
| http://purl.uniprot.org/citations/23075394 | http://purl.org/dc/terms/identifier | "doi:10.1111/tan.12016"xsd:string |
| http://purl.uniprot.org/citations/23075394 | http://purl.uniprot.org/core/author | "Maki M."xsd:string |
| http://purl.uniprot.org/citations/23075394 | http://purl.uniprot.org/core/author | "Lindfors K."xsd:string |
| http://purl.uniprot.org/citations/23075394 | http://purl.uniprot.org/core/author | "Partanen J."xsd:string |
| http://purl.uniprot.org/citations/23075394 | http://purl.uniprot.org/core/author | "Kontula K."xsd:string |
| http://purl.uniprot.org/citations/23075394 | http://purl.uniprot.org/core/author | "Einarsdottir E."xsd:string |
| http://purl.uniprot.org/citations/23075394 | http://purl.uniprot.org/core/author | "Saavalainen P."xsd:string |
| http://purl.uniprot.org/citations/23075394 | http://purl.uniprot.org/core/author | "Kurppa K."xsd:string |
| http://purl.uniprot.org/citations/23075394 | http://purl.uniprot.org/core/author | "Sistonen P."xsd:string |
| http://purl.uniprot.org/citations/23075394 | http://purl.uniprot.org/core/author | "Alakulppi N."xsd:string |
| http://purl.uniprot.org/citations/23075394 | http://purl.uniprot.org/core/author | "Wacklin P."xsd:string |
| http://purl.uniprot.org/citations/23075394 | http://purl.uniprot.org/core/author | "Paavola-Sakki P."xsd:string |
| http://purl.uniprot.org/citations/23075394 | http://purl.uniprot.org/core/author | "Matto J."xsd:string |
| http://purl.uniprot.org/citations/23075394 | http://purl.uniprot.org/core/author | "Lappalainen M."xsd:string |
| http://purl.uniprot.org/citations/23075394 | http://purl.uniprot.org/core/author | "Kaukinen K."xsd:string |
| http://purl.uniprot.org/citations/23075394 | http://purl.uniprot.org/core/author | "Farkkila M."xsd:string |
| http://purl.uniprot.org/citations/23075394 | http://purl.uniprot.org/core/author | "Halme L."xsd:string |
| http://purl.uniprot.org/citations/23075394 | http://purl.uniprot.org/core/author | "Turunen U."xsd:string |
| http://purl.uniprot.org/citations/23075394 | http://purl.uniprot.org/core/author | "Parmar A.S."xsd:string |
| http://purl.uniprot.org/citations/23075394 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23075394 | http://purl.uniprot.org/core/name | "Tissue Antigens"xsd:string |
| http://purl.uniprot.org/citations/23075394 | http://purl.uniprot.org/core/pages | "488-493"xsd:string |
| http://purl.uniprot.org/citations/23075394 | http://purl.uniprot.org/core/title | "Association study of FUT2 (rs601338) with celiac disease and inflammatory bowel disease in the Finnish population."xsd:string |