| http://purl.uniprot.org/citations/23085232 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23085232 | http://www.w3.org/2000/01/rdf-schema#comment | "Matrix metalloproteinase-1 (MMP-1) is a member of the family of zinc-dependent endopeptidases that are capable of degrading extracellular matrix (ECM) and certain non-matrix proteins. It has been shown that MMP-1 can enhance muscle regeneration by improving the differentiation and migration of myoblasts. However, it is still not known whether MMP-1 can promote the myogenesis of bone marrow-derived mesenchymal stem cells (BMSCs). To address this question, we isolated BMSCs from C57BL/6J mice and investigated the effects of MMP-1 on their proliferation and myogenic differentiation. Our results showed that MMP-1 treatment, which had no cytotoxic effects on BMSCs, increased the mRNA and protein levels of MyoD and desmin in a dose-dependent manner, indicating that MMP-1 promoted myogenic differentiation of BMSCs in vitro. These results suggest that BMSCs may have a therapeutic potential for treating muscular disorders."xsd:string |
| http://purl.uniprot.org/citations/23085232 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2012.10.053"xsd:string |
| http://purl.uniprot.org/citations/23085232 | http://purl.uniprot.org/core/author | "Ma Z."xsd:string |
| http://purl.uniprot.org/citations/23085232 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/23085232 | http://purl.uniprot.org/core/author | "Zhou C."xsd:string |
| http://purl.uniprot.org/citations/23085232 | http://purl.uniprot.org/core/author | "Zheng Z."xsd:string |
| http://purl.uniprot.org/citations/23085232 | http://purl.uniprot.org/core/author | "Leng Y."xsd:string |
| http://purl.uniprot.org/citations/23085232 | http://purl.uniprot.org/core/author | "Zhong Z."xsd:string |
| http://purl.uniprot.org/citations/23085232 | http://purl.uniprot.org/core/author | "Shi X.M."xsd:string |
| http://purl.uniprot.org/citations/23085232 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23085232 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/23085232 | http://purl.uniprot.org/core/pages | "309-314"xsd:string |
| http://purl.uniprot.org/citations/23085232 | http://purl.uniprot.org/core/title | "Effects of matrix metalloproteinase-1 on the myogenic differentiation of bone marrow-derived mesenchymal stem cells in vitro."xsd:string |
| http://purl.uniprot.org/citations/23085232 | http://purl.uniprot.org/core/volume | "428"xsd:string |
| http://purl.uniprot.org/citations/23085232 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23085232 |
| http://purl.uniprot.org/citations/23085232 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23085232 |
| http://purl.uniprot.org/uniprot/#_Q9EPL5-mappedCitation-23085232 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23085232 |
| http://purl.uniprot.org/uniprot/Q9EPL5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23085232 |