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http://purl.uniprot.org/citations/23085393http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/23085393http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/23085393http://www.w3.org/2000/01/rdf-schema#comment"We identified urate oxidase (UOX) as a target of SIRT5 by comparing mitochondrial proteins in livers of SIRT5-overexpressing transgenic (SIRT5 Tg) and wild-type mice by using two-dimensional electrophoresis. Acetylation levels of UOX in liver of SIRT5 Tg mice were approximately half of those in wild-type mice, and UOX activity was significantly increased. Invitro-synthesized UOX protein was acetylated when incubated with mitochondria from wild-type mice liver but the levels were less when incubated with those from SIRT5 Tg mice liver. These results suggest that SIRT5 activates UOX through deacetylation in mouse liver mitochondria."xsd:string
http://purl.uniprot.org/citations/23085393http://purl.org/dc/terms/identifier"doi:10.1016/j.febslet.2012.10.009"xsd:string
http://purl.uniprot.org/citations/23085393http://purl.org/dc/terms/identifier"doi:10.1016/j.febslet.2012.10.009"xsd:string
http://purl.uniprot.org/citations/23085393http://purl.uniprot.org/core/author"Nakamura Y."xsd:string
http://purl.uniprot.org/citations/23085393http://purl.uniprot.org/core/author"Nakamura Y."xsd:string
http://purl.uniprot.org/citations/23085393http://purl.uniprot.org/core/author"Ogura K."xsd:string
http://purl.uniprot.org/citations/23085393http://purl.uniprot.org/core/author"Ogura K."xsd:string
http://purl.uniprot.org/citations/23085393http://purl.uniprot.org/core/author"Ogura M."xsd:string
http://purl.uniprot.org/citations/23085393http://purl.uniprot.org/core/author"Ogura M."xsd:string
http://purl.uniprot.org/citations/23085393http://purl.uniprot.org/core/author"Inagaki N."xsd:string
http://purl.uniprot.org/citations/23085393http://purl.uniprot.org/core/author"Inagaki N."xsd:string
http://purl.uniprot.org/citations/23085393http://purl.uniprot.org/core/author"Tanaka D."xsd:string
http://purl.uniprot.org/citations/23085393http://purl.uniprot.org/core/author"Tanaka D."xsd:string
http://purl.uniprot.org/citations/23085393http://purl.uniprot.org/core/date"2012"xsd:gYear
http://purl.uniprot.org/citations/23085393http://purl.uniprot.org/core/date"2012"xsd:gYear
http://purl.uniprot.org/citations/23085393http://purl.uniprot.org/core/name"FEBS Lett."xsd:string
http://purl.uniprot.org/citations/23085393http://purl.uniprot.org/core/name"FEBS Lett."xsd:string
http://purl.uniprot.org/citations/23085393http://purl.uniprot.org/core/pages"4076-4081"xsd:string
http://purl.uniprot.org/citations/23085393http://purl.uniprot.org/core/pages"4076-4081"xsd:string
http://purl.uniprot.org/citations/23085393http://purl.uniprot.org/core/title"SIRT5 deacetylates and activates urate oxidase in liver mitochondria of mice."xsd:string
http://purl.uniprot.org/citations/23085393http://purl.uniprot.org/core/title"SIRT5 deacetylates and activates urate oxidase in liver mitochondria of mice."xsd:string
http://purl.uniprot.org/citations/23085393http://purl.uniprot.org/core/volume"586"xsd:string
http://purl.uniprot.org/citations/23085393http://purl.uniprot.org/core/volume"586"xsd:string