| http://purl.uniprot.org/citations/23086447 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23086447 | http://www.w3.org/2000/01/rdf-schema#comment | "The NF-κB protein RelB controls dendritic cell (DC) maturation and may be targeted therapeutically to manipulate T cell responses in disease. Here we report that RelB promoted DC activation not as the expected RelB-p52 effector of the noncanonical NF-κB pathway, but as a RelB-p50 dimer regulated by canonical IκBs, IκBα and IκBɛ. IκB control of RelB minimized spontaneous maturation but enabled rapid pathogen-responsive maturation. Computational modeling of the NF-κB signaling module identified control points of this unexpected cell type-specific regulation. Fibroblasts that we engineered accordingly showed DC-like RelB control. Canonical pathway control of RelB regulated pathogen-responsive gene expression programs. This work illustrates the potential utility of systems analyses in guiding the development of combination therapeutics for modulating DC-dependent T cell responses."xsd:string |
| http://purl.uniprot.org/citations/23086447 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.2446"xsd:string |
| http://purl.uniprot.org/citations/23086447 | http://purl.uniprot.org/core/author | "Fagerlund R."xsd:string |
| http://purl.uniprot.org/citations/23086447 | http://purl.uniprot.org/core/author | "Yu T."xsd:string |
| http://purl.uniprot.org/citations/23086447 | http://purl.uniprot.org/core/author | "Hoffmann A."xsd:string |
| http://purl.uniprot.org/citations/23086447 | http://purl.uniprot.org/core/author | "Huang J.Q."xsd:string |
| http://purl.uniprot.org/citations/23086447 | http://purl.uniprot.org/core/author | "Asagiri M."xsd:string |
| http://purl.uniprot.org/citations/23086447 | http://purl.uniprot.org/core/author | "Zuniga E.I."xsd:string |
| http://purl.uniprot.org/citations/23086447 | http://purl.uniprot.org/core/author | "Kearns J.D."xsd:string |
| http://purl.uniprot.org/citations/23086447 | http://purl.uniprot.org/core/author | "Macal M."xsd:string |
| http://purl.uniprot.org/citations/23086447 | http://purl.uniprot.org/core/author | "Shih V.F."xsd:string |
| http://purl.uniprot.org/citations/23086447 | http://purl.uniprot.org/core/author | "Davis-Turak J."xsd:string |
| http://purl.uniprot.org/citations/23086447 | http://purl.uniprot.org/core/author | "Ponomarenko J."xsd:string |
| http://purl.uniprot.org/citations/23086447 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23086447 | http://purl.uniprot.org/core/name | "Nat Immunol"xsd:string |
| http://purl.uniprot.org/citations/23086447 | http://purl.uniprot.org/core/pages | "1162-1170"xsd:string |
| http://purl.uniprot.org/citations/23086447 | http://purl.uniprot.org/core/title | "Control of RelB during dendritic cell activation integrates canonical and noncanonical NF-kappaB pathways."xsd:string |
| http://purl.uniprot.org/citations/23086447 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/23086447 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23086447 |
| http://purl.uniprot.org/citations/23086447 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23086447 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGK6-mappedCitation-23086447 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23086447 |
| http://purl.uniprot.org/uniprot/#_A0A140LI24-mappedCitation-23086447 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23086447 |
| http://purl.uniprot.org/uniprot/#_A0A140LI46-mappedCitation-23086447 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23086447 |
| http://purl.uniprot.org/uniprot/#_A0A140LJD6-mappedCitation-23086447 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23086447 |