| http://purl.uniprot.org/citations/23086751 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23086751 | http://www.w3.org/2000/01/rdf-schema#comment | "Delta-like 4 (DLL4), a membrane-bound ligand belonging to the Notch signaling family, plays a fundamental role in vascular development and angiogenesis. We identified a conserved microRNA family, miR-30, which targets DLL4. Overexpression of miR-30b in endothelial cells led to increased vessel number and length in an in vitro model of sprouting angiogenesis. Microinjection of miR-30 mimics into zebrafish embryos resulted in suppression of dll4 and subsequent excessive sprouting of intersegmental vessels and reduction in dorsal aorta diameter. Use of a target protector against the miR-30 site within the dll4 3'UTR up-regulated dll4 and synergized with Vegfa signaling knockdown to inhibit angiogenesis. Furthermore, restoration of miR-30b or miR-30c expression during Kaposi sarcoma herpesvirus (KSHV) infection attenuated viral induction of DLL4. Together these results demonstrate that the highly conserved molecular targeting of DLL4 by the miR-30 family regulates angiogenesis."xsd:string |
| http://purl.uniprot.org/citations/23086751 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2012-04-423004"xsd:string |
| http://purl.uniprot.org/citations/23086751 | http://purl.uniprot.org/core/author | "Patient R."xsd:string |
| http://purl.uniprot.org/citations/23086751 | http://purl.uniprot.org/core/author | "Lagos D."xsd:string |
| http://purl.uniprot.org/citations/23086751 | http://purl.uniprot.org/core/author | "Boshoff C."xsd:string |
| http://purl.uniprot.org/citations/23086751 | http://purl.uniprot.org/core/author | "Henderson S."xsd:string |
| http://purl.uniprot.org/citations/23086751 | http://purl.uniprot.org/core/author | "Monteiro R."xsd:string |
| http://purl.uniprot.org/citations/23086751 | http://purl.uniprot.org/core/author | "Emuss V."xsd:string |
| http://purl.uniprot.org/citations/23086751 | http://purl.uniprot.org/core/author | "Bridge G."xsd:string |
| http://purl.uniprot.org/citations/23086751 | http://purl.uniprot.org/core/author | "Georgopoulou D."xsd:string |
| http://purl.uniprot.org/citations/23086751 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23086751 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/23086751 | http://purl.uniprot.org/core/pages | "5063-5072"xsd:string |
| http://purl.uniprot.org/citations/23086751 | http://purl.uniprot.org/core/title | "The microRNA-30 family targets DLL4 to modulate endothelial cell behavior during angiogenesis."xsd:string |
| http://purl.uniprot.org/citations/23086751 | http://purl.uniprot.org/core/volume | "120"xsd:string |
| http://purl.uniprot.org/citations/23086751 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23086751 |
| http://purl.uniprot.org/citations/23086751 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23086751 |
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| http://purl.uniprot.org/uniprot/#_Q8AXB3-mappedCitation-23086751 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23086751 |