| http://purl.uniprot.org/citations/23090968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23090968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23090968 | http://www.w3.org/2000/01/rdf-schema#comment | "In response to stress, the heart undergoes a pathological remodeling process associated with hypertrophy and the reexpression of a fetal gene program that ultimately causes cardiac dysfunction and heart failure. In this study, we show that A-kinase-anchoring protein (AKAP)-Lbc and the inhibitor of NF-κB kinase subunit β (IKKβ) form a transduction complex in cardiomyocytes that controls the production of proinflammatory cytokines mediating cardiomyocyte hypertrophy. In particular, we can show that activation of IKKβ within the AKAP-Lbc complex promotes NF-κB-dependent production of interleukin-6 (IL-6), which in turn enhances fetal gene expression and cardiomyocyte growth. These findings provide a new mechanistic hypothesis explaining how hypertrophic signals are coordinated and conveyed to interleukin-mediated transcriptional reprogramming events in cardiomyocytes."xsd:string |
| http://purl.uniprot.org/citations/23090968 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.00887-12"xsd:string |
| http://purl.uniprot.org/citations/23090968 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.00887-12"xsd:string |
| http://purl.uniprot.org/citations/23090968 | http://purl.uniprot.org/core/author | "Diviani D."xsd:string |
| http://purl.uniprot.org/citations/23090968 | http://purl.uniprot.org/core/author | "Diviani D."xsd:string |
| http://purl.uniprot.org/citations/23090968 | http://purl.uniprot.org/core/author | "Cotecchia S."xsd:string |
| http://purl.uniprot.org/citations/23090968 | http://purl.uniprot.org/core/author | "Cotecchia S."xsd:string |
| http://purl.uniprot.org/citations/23090968 | http://purl.uniprot.org/core/author | "del Vescovo C.D."xsd:string |
| http://purl.uniprot.org/citations/23090968 | http://purl.uniprot.org/core/author | "del Vescovo C.D."xsd:string |
| http://purl.uniprot.org/citations/23090968 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23090968 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23090968 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/23090968 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/23090968 | http://purl.uniprot.org/core/pages | "14-27"xsd:string |
| http://purl.uniprot.org/citations/23090968 | http://purl.uniprot.org/core/pages | "14-27"xsd:string |
| http://purl.uniprot.org/citations/23090968 | http://purl.uniprot.org/core/title | "A-kinase-anchoring protein-Lbc anchors IkappaB kinase beta to support interleukin-6-mediated cardiomyocyte hypertrophy."xsd:string |
| http://purl.uniprot.org/citations/23090968 | http://purl.uniprot.org/core/title | "A-kinase-anchoring protein-Lbc anchors IkappaB kinase beta to support interleukin-6-mediated cardiomyocyte hypertrophy."xsd:string |
| http://purl.uniprot.org/citations/23090968 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/23090968 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/23090968 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23090968 |
| http://purl.uniprot.org/citations/23090968 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23090968 |
| http://purl.uniprot.org/citations/23090968 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23090968 |
| http://purl.uniprot.org/citations/23090968 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23090968 |