| http://purl.uniprot.org/citations/23091041 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23091041 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23091041 | http://www.w3.org/2000/01/rdf-schema#comment | "T cell-mediated allergy to Ni(++) is one of the most common forms of allergic contact dermatitis, but how the T-cell receptor (TCR) recognizes Ni(++) is unknown. We studied a TCR from an allergic patient that recognizes Ni(++) bound to the MHCII molecule DR52c containing an unknown self-peptide. We identified mimotope peptides that can replace both the self-peptide and Ni(++) in this ligand. They share a p7 lysine whose εNH(2) group is surface-exposed when bound to DR52c. Whereas the TCR uses germ-line complementary-determining region (CDR)1/2 amino acids to dock in the conventional diagonal mode on the mimotope-DR52c complex, the interface is dominated by the TCR Vβ CDR3 interaction with the p7 lysine. Mutations in the TCR CDR loops have similar effects on the T-cell response to either the mimotope or Ni(++) ligand. We suggest that the mimotope p7 lysine mimics Ni(++) in the natural TCR ligand and that MHCII β-chain flexibility in the area around the peptide p7 position forms a common site for cation binding in metal allergies."xsd:string |
| http://purl.uniprot.org/citations/23091041 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1215928109"xsd:string |
| http://purl.uniprot.org/citations/23091041 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1215928109"xsd:string |
| http://purl.uniprot.org/citations/23091041 | http://purl.uniprot.org/core/author | "Dai S."xsd:string |
| http://purl.uniprot.org/citations/23091041 | http://purl.uniprot.org/core/author | "Dai S."xsd:string |
| http://purl.uniprot.org/citations/23091041 | http://purl.uniprot.org/core/author | "Crawford F."xsd:string |
| http://purl.uniprot.org/citations/23091041 | http://purl.uniprot.org/core/author | "Crawford F."xsd:string |
| http://purl.uniprot.org/citations/23091041 | http://purl.uniprot.org/core/author | "Kappler J.W."xsd:string |
| http://purl.uniprot.org/citations/23091041 | http://purl.uniprot.org/core/author | "Kappler J.W."xsd:string |
| http://purl.uniprot.org/citations/23091041 | http://purl.uniprot.org/core/author | "Marrack P."xsd:string |
| http://purl.uniprot.org/citations/23091041 | http://purl.uniprot.org/core/author | "Marrack P."xsd:string |
| http://purl.uniprot.org/citations/23091041 | http://purl.uniprot.org/core/author | "Yin L."xsd:string |
| http://purl.uniprot.org/citations/23091041 | http://purl.uniprot.org/core/author | "Yin L."xsd:string |
| http://purl.uniprot.org/citations/23091041 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23091041 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23091041 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/23091041 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/23091041 | http://purl.uniprot.org/core/pages | "18517-18522"xsd:string |
| http://purl.uniprot.org/citations/23091041 | http://purl.uniprot.org/core/pages | "18517-18522"xsd:string |
| http://purl.uniprot.org/citations/23091041 | http://purl.uniprot.org/core/title | "T-cell receptor (TCR) interaction with peptides that mimic nickel offers insight into nickel contact allergy."xsd:string |
| http://purl.uniprot.org/citations/23091041 | http://purl.uniprot.org/core/title | "T-cell receptor (TCR) interaction with peptides that mimic nickel offers insight into nickel contact allergy."xsd:string |
| http://purl.uniprot.org/citations/23091041 | http://purl.uniprot.org/core/volume | "109"xsd:string |
| http://purl.uniprot.org/citations/23091041 | http://purl.uniprot.org/core/volume | "109"xsd:string |