| http://purl.uniprot.org/citations/23092970 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23092970 | http://www.w3.org/2000/01/rdf-schema#comment | "Heterogeneous ribonucleoprotein-K (hnRNP-K) is normally ubiquitinated by HDM2 for proteasome-mediated degradation. Under DNA-damage conditions, hnRNP-K is transiently stabilized and serves as a transcriptional co-activator of p53 for cell-cycle arrest. However, how the stability and function of hnRNP-K is regulated remained unknown. Here, we demonstrated that UV-induced SUMOylation of hnRNP-K prevents its ubiquitination for stabilization. Using SUMOylation-defective mutant and purified SUMOylated hnRNP-K, SUMOylation was shown to reduce hnRNP-K's affinity to HDM2 with an increase in that to p53 for p21-mediated cell-cycle arrest. PIAS3 served as a small ubiquitin-related modifier (SUMO) E3 ligase for hnRNP-K in an ATR-dependent manner. During later periods after UV exposure, however, SENP2 removed SUMO from hnRNP-K for its destabilization and in turn for release from cell-cycle arrest. Consistent with the rise-and-fall of both SUMOylation and stability of hnRNP-K, its ability to interact with PIAS3 was inversely correlated to that with SENP2 during the time course after UV exposure. These findings indicate that SUMO modification plays a crucial role in the control of hnRNP-K's function as a p53 co-activator in response to DNA damage by UV."xsd:string |
| http://purl.uniprot.org/citations/23092970 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2012.293"xsd:string |
| http://purl.uniprot.org/citations/23092970 | http://purl.uniprot.org/core/author | "Lee M.H."xsd:string |
| http://purl.uniprot.org/citations/23092970 | http://purl.uniprot.org/core/author | "Lee S.W."xsd:string |
| http://purl.uniprot.org/citations/23092970 | http://purl.uniprot.org/core/author | "Park J.H."xsd:string |
| http://purl.uniprot.org/citations/23092970 | http://purl.uniprot.org/core/author | "Chung C.H."xsd:string |
| http://purl.uniprot.org/citations/23092970 | http://purl.uniprot.org/core/author | "Kang S.H."xsd:string |
| http://purl.uniprot.org/citations/23092970 | http://purl.uniprot.org/core/author | "Jeon Y.J."xsd:string |
| http://purl.uniprot.org/citations/23092970 | http://purl.uniprot.org/core/author | "Ka S.H."xsd:string |
| http://purl.uniprot.org/citations/23092970 | http://purl.uniprot.org/core/author | "Yoo H.M."xsd:string |
| http://purl.uniprot.org/citations/23092970 | http://purl.uniprot.org/core/author | "Oh Y.M."xsd:string |
| http://purl.uniprot.org/citations/23092970 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23092970 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/23092970 | http://purl.uniprot.org/core/pages | "4441-4452"xsd:string |
| http://purl.uniprot.org/citations/23092970 | http://purl.uniprot.org/core/title | "SUMOylation of hnRNP-K is required for p53-mediated cell-cycle arrest in response to DNA damage."xsd:string |
| http://purl.uniprot.org/citations/23092970 | http://purl.uniprot.org/core/volume | "31"xsd:string |
| http://purl.uniprot.org/citations/23092970 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23092970 |
| http://purl.uniprot.org/citations/23092970 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23092970 |
| http://purl.uniprot.org/uniprot/#_A0A0M4B4Y9-mappedCitation-23092970 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23092970 |
| http://purl.uniprot.org/uniprot/#_A0A087WXZ1-mappedCitation-23092970 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23092970 |
| http://purl.uniprot.org/uniprot/#_A0A0C4KX50-mappedCitation-23092970 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23092970 |
| http://purl.uniprot.org/uniprot/#_A0A0C4L134-mappedCitation-23092970 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23092970 |
| http://purl.uniprot.org/uniprot/#_A0A087X1Q1-mappedCitation-23092970 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23092970 |
| http://purl.uniprot.org/uniprot/#_A0A218MJE5-mappedCitation-23092970 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23092970 |