| http://purl.uniprot.org/citations/23093933 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23093933 | http://www.w3.org/2000/01/rdf-schema#comment | "Gastric cancer development is strongly correlated with infection by Helicobacter pylori possessing the effector protein CagA. Using a transgenic Drosophila melanogaster model, we show that CagA expression in the simple model epithelium of the larval wing imaginal disc causes dramatic tissue perturbations and apoptosis when CagA-expressing and non-expressing cells are juxtaposed. This cell death phenotype occurs through activation of JNK signaling and is enhanced by loss of the neoplastic tumor suppressors in CagA-expressing cells or loss of the TNF homolog Eiger in wild type neighboring cells. We further explored the effects of CagA-mediated JNK pathway activation on an epithelium in the context of oncogenic Ras activation, using a Drosophila model of metastasis. In this model, CagA expression in epithelial cells enhances the growth and invasion of tumors in a JNK-dependent manner. These data suggest a potential role for CagA-mediated JNK pathway activation in promoting gastric cancer progression."xsd:string |
| http://purl.uniprot.org/citations/23093933 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.ppat.1002939"xsd:string |
| http://purl.uniprot.org/citations/23093933 | http://purl.uniprot.org/core/author | "Guillemin K."xsd:string |
| http://purl.uniprot.org/citations/23093933 | http://purl.uniprot.org/core/author | "Wandler A.M."xsd:string |
| http://purl.uniprot.org/citations/23093933 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23093933 | http://purl.uniprot.org/core/name | "PLoS Pathog"xsd:string |
| http://purl.uniprot.org/citations/23093933 | http://purl.uniprot.org/core/pages | "e1002939"xsd:string |
| http://purl.uniprot.org/citations/23093933 | http://purl.uniprot.org/core/title | "Transgenic expression of the Helicobacter pylori virulence factor CagA promotes apoptosis or tumorigenesis through JNK activation in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/23093933 | http://purl.uniprot.org/core/volume | "8"xsd:string |
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