| http://purl.uniprot.org/citations/23095752 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23095752 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23095752 | http://www.w3.org/2000/01/rdf-schema#comment | "By concerted action in dendritic (DC) and T cells, T-box expressed in T cells (T-bet, Tbx21) is pivotal for initiation and perpetuation of Th1 immunity. Identification of novel T-bet-regulated genes is crucial for further understanding the biology of this transcription factor. By combining siRNA technology with genome-wide mRNA expression analysis, we sought to identify new T-bet-regulated genes in predendritic KG1 cells activated by IL-18. One gene robustly dependent on T-bet was IL-36γ, a recently described novel IL-1 family member. Promoter analysis revealed a T-bet binding site that, along with a κB site, enables efficient IL-36γ induction. Using knock-out animals, IL-36γ reliance on T-bet was extended to murine DC. IL-36γ expression by human myeloid cells was confirmed using monocyte-derived DC and M1 macrophages. The latter model was employed to substantiate dependence of IL-36γ on endogenous T-bet in human primary cells. Ectopic expression of T-bet likewise mediated IL-36γ production in HaCaT keratinocytes that otherwise lack this transcription factor. Additional experiments furthermore revealed that mature IL-36γ has the capability to establish an inflammatory gene expression profile in human primary keratinocytes that displays enhanced mRNA levels for TNFα, CCL20, S100A7, inducible NOS, and IL-36γ itself. Data presented herein shed further light on involvement of T-bet in innate immunity and suggest that IL-36γ, besides IFNγ, may contribute to functions of this transcription factor in immunopathology."xsd:string |
| http://purl.uniprot.org/citations/23095752 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m112.385443"xsd:string |
| http://purl.uniprot.org/citations/23095752 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m112.385443"xsd:string |
| http://purl.uniprot.org/citations/23095752 | http://purl.uniprot.org/core/author | "Bachmann M."xsd:string |
| http://purl.uniprot.org/citations/23095752 | http://purl.uniprot.org/core/author | "Bachmann M."xsd:string |
| http://purl.uniprot.org/citations/23095752 | http://purl.uniprot.org/core/author | "Pfeilschifter J."xsd:string |
| http://purl.uniprot.org/citations/23095752 | http://purl.uniprot.org/core/author | "Pfeilschifter J."xsd:string |
| http://purl.uniprot.org/citations/23095752 | http://purl.uniprot.org/core/author | "Hardle L."xsd:string |
| http://purl.uniprot.org/citations/23095752 | http://purl.uniprot.org/core/author | "Hardle L."xsd:string |
| http://purl.uniprot.org/citations/23095752 | http://purl.uniprot.org/core/author | "Muhl H."xsd:string |
| http://purl.uniprot.org/citations/23095752 | http://purl.uniprot.org/core/author | "Muhl H."xsd:string |
| http://purl.uniprot.org/citations/23095752 | http://purl.uniprot.org/core/author | "Scheiermann P."xsd:string |
| http://purl.uniprot.org/citations/23095752 | http://purl.uniprot.org/core/author | "Scheiermann P."xsd:string |
| http://purl.uniprot.org/citations/23095752 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23095752 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23095752 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/23095752 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/23095752 | http://purl.uniprot.org/core/pages | "41684-41696"xsd:string |
| http://purl.uniprot.org/citations/23095752 | http://purl.uniprot.org/core/pages | "41684-41696"xsd:string |
| http://purl.uniprot.org/citations/23095752 | http://purl.uniprot.org/core/title | "IL-36gamma/IL-1F9, an innate T-bet target in myeloid cells."xsd:string |
| http://purl.uniprot.org/citations/23095752 | http://purl.uniprot.org/core/title | "IL-36gamma/IL-1F9, an innate T-bet target in myeloid cells."xsd:string |
| http://purl.uniprot.org/citations/23095752 | http://purl.uniprot.org/core/volume | "287"xsd:string |
| http://purl.uniprot.org/citations/23095752 | http://purl.uniprot.org/core/volume | "287"xsd:string |