| http://purl.uniprot.org/citations/23097043 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23097043 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23097043 | http://www.w3.org/2000/01/rdf-schema#comment | "The Na(+)/K(+)-ATPase generates ion gradients across the plasma membrane, essential for multiple cellular functions. In mammals, four different Na(+)/K(+)-ATPase α-subunit isoforms are associated with characteristic cell-type expression profiles and kinetics. We found the zebrafish α2Na(+)/K(+)-ATPase associated with striated muscles and that knockdown causes a significant depolarization of the resting membrane potential in slow-twitch fibers of skeletal muscles. Abrupt mechanosensory responses were observed in α2Na(+)/K(+)-ATPase-deficient embryos, possibly linked to a postsynaptic defect. The α2Na(+)/K(+)-ATPase deficiency reduced the heart rate and caused a loss of left-right asymmetry in the heart tube. Similar phenotypes from knockdown of the Na(+)/Ca(2+) exchanger indicated a role for the interplay between these two proteins in the observed phenotypes. Furthermore, proteomics identified up- and downregulation of specific phenotype-related proteins, such as parvalbumin, CaM, GFAP and multiple kinases, thus highlighting a potential proteome change associated with the dynamics of α2Na(+)/K(+)-ATPase. Taken together, our findings show that zebrafish α2Na(+)/K(+)-ATPase is important for skeletal and heart muscle functions."xsd:string |
| http://purl.uniprot.org/citations/23097043 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.115808"xsd:string |
| http://purl.uniprot.org/citations/23097043 | http://purl.uniprot.org/core/author | "Honore B."xsd:string |
| http://purl.uniprot.org/citations/23097043 | http://purl.uniprot.org/core/author | "Honore B."xsd:string |
| http://purl.uniprot.org/citations/23097043 | http://purl.uniprot.org/core/author | "Nissen P."xsd:string |
| http://purl.uniprot.org/citations/23097043 | http://purl.uniprot.org/core/author | "Nissen P."xsd:string |
| http://purl.uniprot.org/citations/23097043 | http://purl.uniprot.org/core/author | "Oxvig C."xsd:string |
| http://purl.uniprot.org/citations/23097043 | http://purl.uniprot.org/core/author | "Oxvig C."xsd:string |
| http://purl.uniprot.org/citations/23097043 | http://purl.uniprot.org/core/author | "Beck H.C."xsd:string |
| http://purl.uniprot.org/citations/23097043 | http://purl.uniprot.org/core/author | "Beck H.C."xsd:string |
| http://purl.uniprot.org/citations/23097043 | http://purl.uniprot.org/core/author | "Kjaer-Sorensen K."xsd:string |
| http://purl.uniprot.org/citations/23097043 | http://purl.uniprot.org/core/author | "Kjaer-Sorensen K."xsd:string |
| http://purl.uniprot.org/citations/23097043 | http://purl.uniprot.org/core/author | "Nyengaard J.R."xsd:string |
| http://purl.uniprot.org/citations/23097043 | http://purl.uniprot.org/core/author | "Nyengaard J.R."xsd:string |
| http://purl.uniprot.org/citations/23097043 | http://purl.uniprot.org/core/author | "Ribera A."xsd:string |
| http://purl.uniprot.org/citations/23097043 | http://purl.uniprot.org/core/author | "Ribera A."xsd:string |
| http://purl.uniprot.org/citations/23097043 | http://purl.uniprot.org/core/author | "Doganli C."xsd:string |
| http://purl.uniprot.org/citations/23097043 | http://purl.uniprot.org/core/author | "Doganli C."xsd:string |
| http://purl.uniprot.org/citations/23097043 | http://purl.uniprot.org/core/author | "Lykke-Hartmann K."xsd:string |
| http://purl.uniprot.org/citations/23097043 | http://purl.uniprot.org/core/author | "Lykke-Hartmann K."xsd:string |
| http://purl.uniprot.org/citations/23097043 | http://purl.uniprot.org/core/author | "Knoeckel C."xsd:string |
| http://purl.uniprot.org/citations/23097043 | http://purl.uniprot.org/core/author | "Knoeckel C."xsd:string |
| http://purl.uniprot.org/citations/23097043 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |