| http://purl.uniprot.org/citations/23099648 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23099648 | http://www.w3.org/2000/01/rdf-schema#comment | "The main objective of this study was to perform a systematic review and meta-analysis on the risk of developing malignant paraganglioma (PGL) in SDHB-mutation and SDHD-mutation carriers. PubMed, EMBASE, Web of Science, COCHRANE and Academic Search Premier (2000-August 2011) and references of key articles were searched to identify potentially relevant studies. The main outcomes were the pooled incidence and prevalence of malignant PGL in SDHB-mutation and SDHD-mutation carriers. A meta-analysis was performed with an exact likelihood approach using a logistic regression with a random effect at the study level. Twelve studies were included. The pooled incidence of malignant PGL in populations comprising both asymptomatic mutation carriers and mutation carriers with manifest non-malignant PGL was 17% (95% CI 10 to 28) for SDHB-mutation carriers and 8% (95% CI 2 to 26) for SDHD-mutation carriers. The pooled risk in prevalence studies was 13% (95% CI 4 to 34) and 4% (95% CI 2 to 7), respectively. In studies comprising only mutation carriers with manifest disease, the pooled prevalence was 23% (95% CI 16 to 33) for SDHB-mutation and 3% (95% CI 1 to 10) for SDHD-mutation carriers. Incidence and prevalence of malignant PGL are higher in SDHB-mutation than in SDHD-mutation carriers, but lower in SDHB-mutation carriers than hitherto appreciated."xsd:string |
| http://purl.uniprot.org/citations/23099648 | http://purl.org/dc/terms/identifier | "doi:10.1136/jmedgenet-2012-101192"xsd:string |
| http://purl.uniprot.org/citations/23099648 | http://purl.uniprot.org/core/author | "Smit J.W."xsd:string |
| http://purl.uniprot.org/citations/23099648 | http://purl.uniprot.org/core/author | "Corssmit E.P."xsd:string |
| http://purl.uniprot.org/citations/23099648 | http://purl.uniprot.org/core/author | "Hes F.J."xsd:string |
| http://purl.uniprot.org/citations/23099648 | http://purl.uniprot.org/core/author | "Dekkers O.M."xsd:string |
| http://purl.uniprot.org/citations/23099648 | http://purl.uniprot.org/core/author | "van Hulsteijn L.T."xsd:string |
| http://purl.uniprot.org/citations/23099648 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23099648 | http://purl.uniprot.org/core/name | "J Med Genet"xsd:string |
| http://purl.uniprot.org/citations/23099648 | http://purl.uniprot.org/core/pages | "768-776"xsd:string |
| http://purl.uniprot.org/citations/23099648 | http://purl.uniprot.org/core/title | "Risk of malignant paraganglioma in SDHB-mutation and SDHD-mutation carriers: a systematic review and meta-analysis."xsd:string |
| http://purl.uniprot.org/citations/23099648 | http://purl.uniprot.org/core/volume | "49"xsd:string |
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