| http://purl.uniprot.org/citations/23100088 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23100088 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundPatients with Takayasu arteritis (TA) often show recurrence under steroid treatment without an elevation of C-reactive protein (CRP). There is a report that matrix metalloproteinase (MMP)-2, MMP-3, MMP-9 and pentraxin3 (PTX3) could be sensitive biomarkers, but the characteristics of these biomarkers have not been established.Methods and resultsWe enrolled 45 consecutive patients; 28 were grouped in an active phase as evidenced by clinical recurrence within 2 years of blood sampling. Circulating levels of high-sensitivity (hs)CRP, MMPs, and PTX3 were determined. Patients in an active phase showed higher levels of hsCRP, MMP-9, and PTX3. Area under the receiving operating characteristics curves of hsCRP and PTX3 were significantly higher than that of MMP-9. Among the 28 patients with active TA, 71% was positive for hsCRP and 82% for PTX3. Patients without recurrence showed significantly higher plasma levels of MMP-9. There was a positive correlation between the plasma MMP-3 level and the prednisolone dose. However, PTX3 and MMP-9 levels did not have such a correlation.ConclusionsPTX3 and MMP-9, which are not affected by prednisolone, could be sensitive biomarkers for assessing TA activity. Evaluation of MMP-9 may suggest prior existence of TA."xsd:string |
| http://purl.uniprot.org/citations/23100088 | http://purl.org/dc/terms/identifier | "doi:10.1253/circj.cj-12-0131"xsd:string |
| http://purl.uniprot.org/citations/23100088 | http://purl.uniprot.org/core/author | "Inagaki H."xsd:string |
| http://purl.uniprot.org/citations/23100088 | http://purl.uniprot.org/core/author | "Ishihara T."xsd:string |
| http://purl.uniprot.org/citations/23100088 | http://purl.uniprot.org/core/author | "Haraguchi G."xsd:string |
| http://purl.uniprot.org/citations/23100088 | http://purl.uniprot.org/core/author | "Isobe M."xsd:string |
| http://purl.uniprot.org/citations/23100088 | http://purl.uniprot.org/core/author | "Tezuka D."xsd:string |
| http://purl.uniprot.org/citations/23100088 | http://purl.uniprot.org/core/author | "Kamiishi T."xsd:string |
| http://purl.uniprot.org/citations/23100088 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23100088 | http://purl.uniprot.org/core/name | "Circ J"xsd:string |
| http://purl.uniprot.org/citations/23100088 | http://purl.uniprot.org/core/pages | "477-483"xsd:string |
| http://purl.uniprot.org/citations/23100088 | http://purl.uniprot.org/core/title | "Diagnosis and assessment of Takayasu arteritis by multiple biomarkers."xsd:string |
| http://purl.uniprot.org/citations/23100088 | http://purl.uniprot.org/core/volume | "77"xsd:string |
| http://purl.uniprot.org/citations/23100088 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23100088 |
| http://purl.uniprot.org/citations/23100088 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23100088 |
| http://purl.uniprot.org/uniprot/#_A0A0U3J4I2-mappedCitation-23100088 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23100088 |
| http://purl.uniprot.org/uniprot/#_A5GZ70-mappedCitation-23100088 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23100088 |
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| http://purl.uniprot.org/uniprot/#_B7Z8A9-mappedCitation-23100088 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23100088 |
| http://purl.uniprot.org/uniprot/#_F2YBS6-mappedCitation-23100088 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23100088 |
| http://purl.uniprot.org/uniprot/#_P08253-mappedCitation-23100088 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23100088 |
| http://purl.uniprot.org/uniprot/#_P08254-mappedCitation-23100088 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23100088 |