| http://purl.uniprot.org/citations/23100419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23100419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23100419 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutations in several postsynaptic proteins have recently been implicated in the molecular pathogenesis of autism and autism spectrum disorders (ASDs), including Neuroligins, Neurexins, and members of the ProSAP/Shank family, thereby suggesting that these genetic forms of autism may share common synaptic mechanisms. Initial studies of ASD-associated mutations in ProSAP2/Shank3 support a role for this protein in glutamate receptor function and spine morphology, but these synaptic phenotypes are not universally penetrant, indicating that other core facets of ProSAP2/Shank3 function must underlie synaptic deficits in patients with ASDs. In the present study, we have examined whether the ability of ProSAP2/Shank3 to interact with the cytoplasmic tail of Neuroligins functions to coordinate pre/postsynaptic signaling through the Neurexin-Neuroligin signaling complex in hippocampal neurons of Rattus norvegicus. Indeed, we find that synaptic levels of ProSAP2/Shank3 regulate AMPA and NMDA receptor-mediated synaptic transmission and induce widespread changes in the levels of presynaptic and postsynaptic proteins via Neurexin-Neuroligin transsynaptic signaling. ASD-associated mutations in ProSAP2/Shank3 disrupt not only postsynaptic AMPA and NMDA receptor signaling but also interfere with the ability of ProSAP2/Shank3 to signal across the synapse to alter presynaptic structure and function. These data indicate that ASD-associated mutations in a subset of synaptic proteins may target core cellular pathways that coordinate the functional matching and maturation of excitatory synapses in the CNS."xsd:string |
| http://purl.uniprot.org/citations/23100419 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.2215-12.2012"xsd:string |
| http://purl.uniprot.org/citations/23100419 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.2215-12.2012"xsd:string |
| http://purl.uniprot.org/citations/23100419 | http://purl.uniprot.org/core/author | "Li D."xsd:string |
| http://purl.uniprot.org/citations/23100419 | http://purl.uniprot.org/core/author | "Li D."xsd:string |
| http://purl.uniprot.org/citations/23100419 | http://purl.uniprot.org/core/author | "Boeckers T.M."xsd:string |
| http://purl.uniprot.org/citations/23100419 | http://purl.uniprot.org/core/author | "Boeckers T.M."xsd:string |
| http://purl.uniprot.org/citations/23100419 | http://purl.uniprot.org/core/author | "Garner C.C."xsd:string |
| http://purl.uniprot.org/citations/23100419 | http://purl.uniprot.org/core/author | "Garner C.C."xsd:string |
| http://purl.uniprot.org/citations/23100419 | http://purl.uniprot.org/core/author | "Schoen M."xsd:string |
| http://purl.uniprot.org/citations/23100419 | http://purl.uniprot.org/core/author | "Schoen M."xsd:string |
| http://purl.uniprot.org/citations/23100419 | http://purl.uniprot.org/core/author | "Grabrucker A.M."xsd:string |
| http://purl.uniprot.org/citations/23100419 | http://purl.uniprot.org/core/author | "Grabrucker A.M."xsd:string |
| http://purl.uniprot.org/citations/23100419 | http://purl.uniprot.org/core/author | "Montgomery J.M."xsd:string |
| http://purl.uniprot.org/citations/23100419 | http://purl.uniprot.org/core/author | "Montgomery J.M."xsd:string |
| http://purl.uniprot.org/citations/23100419 | http://purl.uniprot.org/core/author | "Arons M.H."xsd:string |
| http://purl.uniprot.org/citations/23100419 | http://purl.uniprot.org/core/author | "Arons M.H."xsd:string |
| http://purl.uniprot.org/citations/23100419 | http://purl.uniprot.org/core/author | "Cheyne J.E."xsd:string |
| http://purl.uniprot.org/citations/23100419 | http://purl.uniprot.org/core/author | "Cheyne J.E."xsd:string |
| http://purl.uniprot.org/citations/23100419 | http://purl.uniprot.org/core/author | "Thynne C.J."xsd:string |
| http://purl.uniprot.org/citations/23100419 | http://purl.uniprot.org/core/author | "Thynne C.J."xsd:string |
| http://purl.uniprot.org/citations/23100419 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23100419 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |