| http://purl.uniprot.org/citations/23104860 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23104860 | http://www.w3.org/2000/01/rdf-schema#comment | "Oxidative DNA damage accumulates with age and is repaired primarily via the base excision repair (BER) pathway. This process is initiated by DNA glycosylases, which remove damaged bases in a substrate-specific manner. The DNA glycosylases human 8-oxoguanine-DNA glycosylase (OGG1) and NEIL1, a mammalian homolog ofEscherichia coli endonuclease VIII, have overlapping yet distinct substrate specificity. Recently, we reported that OGG1 binds to the Poly(ADP-ribose) polymerase 1 (PARP-1), a DNA damage sensor protein that poly(ADP-ribosyl)ates nuclear proteins in response to DNA damage and other cellular signals. Here, we show that NEIL1 and PARP-1 bind both in vitro and in vivo. PARP-1 binds to the C-terminal-100 amino acids of NEIL1 and NEIL1 binds to the BRCT domain of PARP-1. NEIL1 stimulates the poly(ADP-ribosyl)ation activity of PARP-1. Furthermore, NEIL-deficient fibroblasts have impaired poly(ADP-ribosyl)ation of cellular proteins after DNA damage, which can be rescued by NEIL1 expression. Additionally, PARP-1 inhibits NEIL1 incision activity in a concentration-dependent manner. Consistent with the idea of impaired DNA repair during aging, we observed differential binding of PARP-1 to recombinant NEIL1 in older mice compared to younger mice. These data further support the idea that dynamic interplay between different base excision repair proteins is important for efficient BER."xsd:string |
| http://purl.uniprot.org/citations/23104860 | http://purl.org/dc/terms/identifier | "doi:10.18632/aging.100492"xsd:string |
| http://purl.uniprot.org/citations/23104860 | http://purl.uniprot.org/core/author | "Nagle J."xsd:string |
| http://purl.uniprot.org/citations/23104860 | http://purl.uniprot.org/core/author | "Barnes J."xsd:string |
| http://purl.uniprot.org/citations/23104860 | http://purl.uniprot.org/core/author | "Fitzpatrick M."xsd:string |
| http://purl.uniprot.org/citations/23104860 | http://purl.uniprot.org/core/author | "Moore B.R."xsd:string |
| http://purl.uniprot.org/citations/23104860 | http://purl.uniprot.org/core/author | "Evans M.K."xsd:string |
| http://purl.uniprot.org/citations/23104860 | http://purl.uniprot.org/core/author | "Lohani A."xsd:string |
| http://purl.uniprot.org/citations/23104860 | http://purl.uniprot.org/core/author | "Kompaniez K."xsd:string |
| http://purl.uniprot.org/citations/23104860 | http://purl.uniprot.org/core/author | "Noren Hooten N."xsd:string |
| http://purl.uniprot.org/citations/23104860 | http://purl.uniprot.org/core/author | "Jacob K.D."xsd:string |
| http://purl.uniprot.org/citations/23104860 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23104860 | http://purl.uniprot.org/core/name | "Aging (Albany NY)"xsd:string |
| http://purl.uniprot.org/citations/23104860 | http://purl.uniprot.org/core/pages | "674-685"xsd:string |
| http://purl.uniprot.org/citations/23104860 | http://purl.uniprot.org/core/title | "Coordination of DNA repair by NEIL1 and PARP-1: a possible link to aging."xsd:string |
| http://purl.uniprot.org/citations/23104860 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/23104860 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23104860 |
| http://purl.uniprot.org/citations/23104860 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23104860 |
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| http://purl.uniprot.org/uniprot/#_P09874-mappedCitation-23104860 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23104860 |
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| http://purl.uniprot.org/uniprot/#_Q3U868-mappedCitation-23104860 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23104860 |