| http://purl.uniprot.org/citations/23108047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23108047 | http://www.w3.org/2000/01/rdf-schema#comment | "CCDC6 is rearranged in approximately 20% of papillary thyroid carcinomas and some lung cancers participating in the formation of PTC1/ret proto-oncogene oncogene. CCDC6 is involved in the cellular response to DNA damage and is stabilized by ATM-mediated phosphorylation at Thr434. However, the E3 ligase that targets CCDC6 for destruction is unknown. Here, we show that FBXW7 interacts with and targets CCDC6 for ubiquitin-mediated proteasomal degradation. Moreover, FBXW7-mediated CCDC6 degradation is impaired in response to DNA damage. Mechanistically, phosphorylation of CCDC6 at Thr434 by ATM during DNA damage response prevents FBXW6-CCDC6 interaction and FBXW7-mediated CCDC6 degradation. Our results suggest that the involvement of FBXW7 in targeting CCDC6 for destruction will be useful for the establishment of new therapeutic approaches for cancer treatment."xsd:string |
| http://purl.uniprot.org/citations/23108047 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2012.10.029"xsd:string |
| http://purl.uniprot.org/citations/23108047 | http://purl.uniprot.org/core/author | "Zhao J."xsd:string |
| http://purl.uniprot.org/citations/23108047 | http://purl.uniprot.org/core/author | "Tang J."xsd:string |
| http://purl.uniprot.org/citations/23108047 | http://purl.uniprot.org/core/author | "Ren K."xsd:string |
| http://purl.uniprot.org/citations/23108047 | http://purl.uniprot.org/core/author | "Men W."xsd:string |
| http://purl.uniprot.org/citations/23108047 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23108047 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/23108047 | http://purl.uniprot.org/core/pages | "4257-4263"xsd:string |
| http://purl.uniprot.org/citations/23108047 | http://purl.uniprot.org/core/title | "FBXW7-mediated degradation of CCDC6 is impaired by ATM during DNA damage response in lung cancer cells."xsd:string |
| http://purl.uniprot.org/citations/23108047 | http://purl.uniprot.org/core/volume | "586"xsd:string |
| http://purl.uniprot.org/citations/23108047 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23108047 |
| http://purl.uniprot.org/citations/23108047 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23108047 |
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| http://purl.uniprot.org/uniprot/#_B7Z2C8-mappedCitation-23108047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23108047 |
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| http://purl.uniprot.org/uniprot/#_Q53F40-mappedCitation-23108047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23108047 |
| http://purl.uniprot.org/uniprot/#_Q13616-mappedCitation-23108047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23108047 |
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| http://purl.uniprot.org/uniprot/#_Q59ET6-mappedCitation-23108047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23108047 |