| http://purl.uniprot.org/citations/23110853 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23110853 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23110853 | http://www.w3.org/2000/01/rdf-schema#comment | "Hydroxyacid dehydrogenases, responsible for the stereospecific conversion of 2-keto acids to 2-hydroxyacids in lactic acid producing bacteria, have a range of biotechnology applications including antibiotic synthesis, flavor development in dairy products and the production of valuable synthons. The genome of Lactobacillus delbrueckii ssp. bulgaricus, a member of the heterogeneous group of lactic acid bacteria, encodes multiple hydroxyacid dehydrogenases whose structural and functional properties remain poorly characterized. Here, we report the apo and coenzyme NAD⁺ complexed crystal structures of the L. bulgaricusD-isomer specific 2-hydroxyacid dehydrogenase, D2-HDH. Comparison with closely related members of the NAD-dependent dehydrogenase family reveals that whilst the D2-HDH core fold is structurally conserved, the substrate-binding site has a number of non-canonical features that may influence substrate selection and thus dictate the physiological function of the enzyme."xsd:string |
| http://purl.uniprot.org/citations/23110853 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jsb.2012.10.009"xsd:string |
| http://purl.uniprot.org/citations/23110853 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jsb.2012.10.009"xsd:string |
| http://purl.uniprot.org/citations/23110853 | http://purl.uniprot.org/core/author | "Wilmanns M."xsd:string |
| http://purl.uniprot.org/citations/23110853 | http://purl.uniprot.org/core/author | "Wilmanns M."xsd:string |
| http://purl.uniprot.org/citations/23110853 | http://purl.uniprot.org/core/author | "Anandhakrishnan M."xsd:string |
| http://purl.uniprot.org/citations/23110853 | http://purl.uniprot.org/core/author | "Anandhakrishnan M."xsd:string |
| http://purl.uniprot.org/citations/23110853 | http://purl.uniprot.org/core/author | "Holton S.J."xsd:string |
| http://purl.uniprot.org/citations/23110853 | http://purl.uniprot.org/core/author | "Holton S.J."xsd:string |
| http://purl.uniprot.org/citations/23110853 | http://purl.uniprot.org/core/author | "Geerlof A."xsd:string |
| http://purl.uniprot.org/citations/23110853 | http://purl.uniprot.org/core/author | "Geerlof A."xsd:string |
| http://purl.uniprot.org/citations/23110853 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23110853 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23110853 | http://purl.uniprot.org/core/name | "J. Struct. Biol."xsd:string |
| http://purl.uniprot.org/citations/23110853 | http://purl.uniprot.org/core/name | "J Struct Biol"xsd:string |
| http://purl.uniprot.org/citations/23110853 | http://purl.uniprot.org/core/pages | "179-184"xsd:string |
| http://purl.uniprot.org/citations/23110853 | http://purl.uniprot.org/core/pages | "179-184"xsd:string |
| http://purl.uniprot.org/citations/23110853 | http://purl.uniprot.org/core/title | "Structural characterization of a D-isomer specific 2-hydroxyacid dehydrogenase from Lactobacillus delbrueckii ssp. bulgaricus."xsd:string |
| http://purl.uniprot.org/citations/23110853 | http://purl.uniprot.org/core/title | "Structural characterization of a D-isomer specific 2-hydroxyacid dehydrogenase from Lactobacillus delbrueckii ssp. bulgaricus."xsd:string |
| http://purl.uniprot.org/citations/23110853 | http://purl.uniprot.org/core/volume | "181"xsd:string |
| http://purl.uniprot.org/citations/23110853 | http://purl.uniprot.org/core/volume | "181"xsd:string |
| http://purl.uniprot.org/citations/23110853 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23110853 |
| http://purl.uniprot.org/citations/23110853 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23110853 |