| http://purl.uniprot.org/citations/23112125 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23112125 | http://www.w3.org/2000/01/rdf-schema#comment | "CD19-deficient mice were used as a model to study follicular dendritic cell (FDC) activation because these mice have normal numbers of FDC-containing primary follicles, but lack the ability to activate FDCs or form GCs. It was hypothesized that CD19 expression is necessary for B-cell activation and upregulation of membrane lymphotoxin (mLT) expression, which promotes FDC activation. Using VCAM-1 and FcγRII/III as FDC activation markers, it was determined that the adoptive transfer of CD19(+) wild-type B cells into CD19-deficient hosts rescued GC formation and FDC activation, demonstrating that CD19 expression on B cells is required for FDC activation. In contrast, CD19(+) donor B cells lacking mLT were unable to induce VCAM-1 expression on FDCs, furthermore FcγRII/III upregulation was impaired in FDCs stimulated with mLT-deficient B cells. VCAM-1 expression on FDCs, but not FcγRII/III, was rescued when CD19-deficient B cells expressing transgenic mLT were cotransferred into recipient mice with CD19(+) , mLT-deficient B cells, suggesting that FDC activation requires the CD19-dependent upregulation of mLT on activated B cells. Collectively, these data demonstrate that activated B cells are responsible for the initiation of FDC activation resulting in a microenvironment supportive of GC development and maintenance."xsd:string |
| http://purl.uniprot.org/citations/23112125 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.201242471"xsd:string |
| http://purl.uniprot.org/citations/23112125 | http://purl.uniprot.org/core/author | "Justement L.B."xsd:string |
| http://purl.uniprot.org/citations/23112125 | http://purl.uniprot.org/core/author | "King R.G."xsd:string |
| http://purl.uniprot.org/citations/23112125 | http://purl.uniprot.org/core/author | "Carter R.H."xsd:string |
| http://purl.uniprot.org/citations/23112125 | http://purl.uniprot.org/core/author | "Myers R.C."xsd:string |
| http://purl.uniprot.org/citations/23112125 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23112125 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/23112125 | http://purl.uniprot.org/core/pages | "348-359"xsd:string |
| http://purl.uniprot.org/citations/23112125 | http://purl.uniprot.org/core/title | "Lymphotoxin alpha1beta2 expression on B cells is required for follicular dendritic cell activation during the germinal center response."xsd:string |
| http://purl.uniprot.org/citations/23112125 | http://purl.uniprot.org/core/volume | "43"xsd:string |
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