| http://purl.uniprot.org/citations/23112162 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23112162 | http://www.w3.org/2000/01/rdf-schema#comment | "Intestinal metaplasia of the stomach, a mucosal change characterized by the conversion of gastric epithelium into an intestinal phenotype, is a precancerous lesion from which intestinal-type gastric adenocarcinoma arises. Chronic infection with Helicobacter pylori is a major cause of gastric intestinal metaplasia, and aberrant induction by H. pylori of the intestine-specific caudal-related homeobox (CDX) transcription factors, CDX1 and CDX2, plays a key role in this metaplastic change. As such, a critical issue arises as to how these factors govern the cell- and tissue-type switching. In this study, we explored genes directly activated by CDX1 in gastric epithelial cells and identified stemness-associated reprogramming factors SALL4 and KLF5. Indeed, SALL4 and KLF5 were aberrantly expressed in the CDX1(+) intestinal metaplasia of the stomach in both humans and mice. In cultured gastric epithelial cells, sustained expression of CDX1 gave rise to the induction of early intestinal-stemness markers, followed by the expression of intestinal-differentiation markers. Furthermore, the induction of these markers was suppressed by inhibiting either SALL4 or KLF5 expression, indicating that CDX1-induced SALL4 and KLF5 converted gastric epithelial cells into tissue stem-like progenitor cells, which then transdifferentiated into intestinal epithelial cells. Our study places the stemness-related reprogramming factors as critical components of CDX1-directed transcriptional circuitries that promote intestinal metaplasia. Requirement of a transit through dedifferentiated stem/progenitor-like cells, which share properties in common with cancer stem cells, may underlie predisposition of intestinal metaplasia to neoplastic transformation."xsd:string |
| http://purl.uniprot.org/citations/23112162 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1208651109"xsd:string |
| http://purl.uniprot.org/citations/23112162 | http://purl.uniprot.org/core/author | "Fujii Y."xsd:string |
| http://purl.uniprot.org/citations/23112162 | http://purl.uniprot.org/core/author | "Maeda S."xsd:string |
| http://purl.uniprot.org/citations/23112162 | http://purl.uniprot.org/core/author | "Suzuki H."xsd:string |
| http://purl.uniprot.org/citations/23112162 | http://purl.uniprot.org/core/author | "Yamagata Y."xsd:string |
| http://purl.uniprot.org/citations/23112162 | http://purl.uniprot.org/core/author | "Aburatani H."xsd:string |
| http://purl.uniprot.org/citations/23112162 | http://purl.uniprot.org/core/author | "Tsutsumi S."xsd:string |
| http://purl.uniprot.org/citations/23112162 | http://purl.uniprot.org/core/author | "Seto Y."xsd:string |
| http://purl.uniprot.org/citations/23112162 | http://purl.uniprot.org/core/author | "Hatakeyama M."xsd:string |
| http://purl.uniprot.org/citations/23112162 | http://purl.uniprot.org/core/author | "Mutoh H."xsd:string |
| http://purl.uniprot.org/citations/23112162 | http://purl.uniprot.org/core/author | "Yoshihashi K."xsd:string |
| http://purl.uniprot.org/citations/23112162 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23112162 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/23112162 | http://purl.uniprot.org/core/pages | "20584-20589"xsd:string |
| http://purl.uniprot.org/citations/23112162 | http://purl.uniprot.org/core/title | "CDX1 confers intestinal phenotype on gastric epithelial cells via induction of stemness-associated reprogramming factors SALL4 and KLF5."xsd:string |
| http://purl.uniprot.org/citations/23112162 | http://purl.uniprot.org/core/volume | "109"xsd:string |
| http://purl.uniprot.org/citations/23112162 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23112162 |
| http://purl.uniprot.org/citations/23112162 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23112162 |
| http://purl.uniprot.org/uniprot/#_A0A0A0N0L4-mappedCitation-23112162 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23112162 |
| http://purl.uniprot.org/uniprot/#_A0A0A0N0L7-mappedCitation-23112162 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23112162 |
| http://purl.uniprot.org/uniprot/#_A0A0A0N0M4-mappedCitation-23112162 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23112162 |
| http://purl.uniprot.org/uniprot/#_Q14DX0-mappedCitation-23112162 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23112162 |
| http://purl.uniprot.org/uniprot/#_A2AUZ6-mappedCitation-23112162 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23112162 |