| http://purl.uniprot.org/citations/23113638 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23113638 | http://www.w3.org/2000/01/rdf-schema#comment | "Acute graft-versus-host disease (GVHD) is the most important cause of mortality after allogeneic haematopoietic stem cell transplantation. Allo-reactive T cells are the major mediators of GVHD and the process is regulated by positive and negative regulators on antigen-presenting cells (APC). Because the significance of negative regulators in GVHD pathogenesis is not fully understood, and having discovered that syndecan-4 (SD-4) on effector T cells mediates the inhibitory function of DC-HIL on APC, we proposed that SD-4 negatively regulates the T-cell response to allo-stimulation in acute GVHD, using SD-4 knockout mice. Although not different from their wild-type counterparts in responsiveness to anti-CD3 stimulation, SD-4(-/-) T cells lost the capacity to mediate the inhibitory function of DC-HIL and were hyper-reactive to allogeneic APC. Moreover, infusion of SD-4(-/-) T cells into sub-lethally γ-irradiated allogeneic mice worsened mortality, with hyper-proliferation of infused T cells in recipients. Although there my be little or no involvement of regulatory T cells in this model because SD-4 deletion had no deleterious effect on T-cell-suppressive activity compared with SD-4(+/+) regulatory T cells. We conclude that SD-4, as the T-cell ligand of DC-HIL, is a potent inhibitor of allo-reactive T cells responsible for GVHD and a potentially useful target for treating this disease."xsd:string |
| http://purl.uniprot.org/citations/23113638 | http://purl.org/dc/terms/identifier | "doi:10.1111/imm.12027"xsd:string |
| http://purl.uniprot.org/citations/23113638 | http://purl.uniprot.org/core/author | "Tamura K."xsd:string |
| http://purl.uniprot.org/citations/23113638 | http://purl.uniprot.org/core/author | "Kojima T."xsd:string |
| http://purl.uniprot.org/citations/23113638 | http://purl.uniprot.org/core/author | "Chung J.S."xsd:string |
| http://purl.uniprot.org/citations/23113638 | http://purl.uniprot.org/core/author | "Ariizumi K."xsd:string |
| http://purl.uniprot.org/citations/23113638 | http://purl.uniprot.org/core/author | "Cruz P.D. Jr."xsd:string |
| http://purl.uniprot.org/citations/23113638 | http://purl.uniprot.org/core/author | "Tomihari M."xsd:string |
| http://purl.uniprot.org/citations/23113638 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23113638 | http://purl.uniprot.org/core/name | "Immunology"xsd:string |
| http://purl.uniprot.org/citations/23113638 | http://purl.uniprot.org/core/pages | "173-182"xsd:string |
| http://purl.uniprot.org/citations/23113638 | http://purl.uniprot.org/core/title | "The DC-HIL ligand syndecan-4 is a negative regulator of T-cell allo-reactivity responsible for graft-versus-host disease."xsd:string |
| http://purl.uniprot.org/citations/23113638 | http://purl.uniprot.org/core/volume | "138"xsd:string |
| http://purl.uniprot.org/citations/23113638 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23113638 |
| http://purl.uniprot.org/citations/23113638 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23113638 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SVG5-mappedCitation-23113638 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23113638 |
| http://purl.uniprot.org/uniprot/#_O35988-mappedCitation-23113638 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23113638 |
| http://purl.uniprot.org/uniprot/#_Q3UKZ1-mappedCitation-23113638 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23113638 |
| http://purl.uniprot.org/uniprot/#_Q3TXG7-mappedCitation-23113638 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23113638 |
| http://purl.uniprot.org/uniprot/#_Q99LM6-mappedCitation-23113638 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23113638 |
| http://purl.uniprot.org/uniprot/#_Q3UE75-mappedCitation-23113638 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23113638 |
| http://purl.uniprot.org/uniprot/#_Q3TWC7-mappedCitation-23113638 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23113638 |
| http://purl.uniprot.org/uniprot/#_Q3TAV1-mappedCitation-23113638 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23113638 |
| http://purl.uniprot.org/uniprot/#_Q3TBB0-mappedCitation-23113638 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23113638 |