| http://purl.uniprot.org/citations/23119005 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23119005 | http://www.w3.org/2000/01/rdf-schema#comment | "Celiac disease (CD) is a chronic inflammatory disorder triggered after gluten ingestion in genetically susceptible individuals. The major genetic determinants are HLA-DQA1*05 and HLA-DQB1*02, which encode the DQ2 heterodimer. These alleles are commonly inherited in cis with DRB1*03∶01, which is associated with numerous immune-related disorders, in some cases contributing with a different amount of risk depending on the haplotype context. We aimed at investigating those possible differences involving DRB1*03∶01-carrying haplotypes in CD susceptibility. A family (274 trios) and a case-control sample (369 CD cases/461 controls) were analyzed. DRB1*03∶01-carrying individuals were classified according to the haplotype present (ancestral haplotype (AH) 8.1, AH 18.2 or non-conserved haplotype) after genotyping of HLA-DRB1, -DQA1, -DQB1, -B8, TNF -308, TNF -376 and the TNFa and TNFb microsatellites. We observe that the AH 8.1 confers higher risk than the remaining DRB1*03∶01-carrying haplotypes, and this effect only involves individuals possessing a single copy of DQB1*02. CD risk for these individuals is similar to the one conferred by inherit DQA1*05 and DQB1*02 in trans. It seems that an additional CD susceptibility factor is present in the AH 8.1 but not in other DRB1*03∶01-carrying haplotypes. This factor could be shared with individuals possessing DQ2.5 trans, according to the similar risk observed in those two groups of individuals."xsd:string |
| http://purl.uniprot.org/citations/23119005 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0048403"xsd:string |
| http://purl.uniprot.org/citations/23119005 | http://purl.uniprot.org/core/author | "Nunez C."xsd:string |
| http://purl.uniprot.org/citations/23119005 | http://purl.uniprot.org/core/author | "Fernandez-Arquero M."xsd:string |
| http://purl.uniprot.org/citations/23119005 | http://purl.uniprot.org/core/author | "Figueredo M.A."xsd:string |
| http://purl.uniprot.org/citations/23119005 | http://purl.uniprot.org/core/author | "Maluenda C."xsd:string |
| http://purl.uniprot.org/citations/23119005 | http://purl.uniprot.org/core/author | "Dema B."xsd:string |
| http://purl.uniprot.org/citations/23119005 | http://purl.uniprot.org/core/author | "Medrano L.M."xsd:string |
| http://purl.uniprot.org/citations/23119005 | http://purl.uniprot.org/core/author | "Bodas A."xsd:string |
| http://purl.uniprot.org/citations/23119005 | http://purl.uniprot.org/core/author | "Lopez-Larios A."xsd:string |
| http://purl.uniprot.org/citations/23119005 | http://purl.uniprot.org/core/author | "Lopez-Palacios N."xsd:string |
| http://purl.uniprot.org/citations/23119005 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23119005 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/23119005 | http://purl.uniprot.org/core/pages | "e48403"xsd:string |
| http://purl.uniprot.org/citations/23119005 | http://purl.uniprot.org/core/title | "HLA and celiac disease susceptibility: new genetic factors bring open questions about the HLA influence and gene-dosage effects."xsd:string |
| http://purl.uniprot.org/citations/23119005 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/23119005 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23119005 |
| http://purl.uniprot.org/citations/23119005 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23119005 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-23119005 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23119005 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-23119005 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23119005 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-23119005 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23119005 |
| http://purl.uniprot.org/uniprot/#_A0A0A0WDZ3-mappedCitation-23119005 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23119005 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DD60-mappedCitation-23119005 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23119005 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DD66-mappedCitation-23119005 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23119005 |