| http://purl.uniprot.org/citations/23123158 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23123158 | http://www.w3.org/2000/01/rdf-schema#comment | "Mitochondrial dynamics and mitophagy are thought to be important events for the quality control of mitochondria and mitochondria-associated diseases. To identify novel mitophagy modulators, we developed a cell-based screening system and selected 1,10-phenanthroline (Phen) as a target molecule. Phen treatment highly induced mitochondrial fragmentation and mitochondrial dysfunctions in a Drp1 dependent manner. Phen treatment also increased autophagy. Moreover, prolonged exposure of Phen increased mitochondria clearance through mitophagy. Phen-mediated loss of mitochondrial mass was more reduced in ATG5 deficient cells than in wild type cells. In addition, down-regulation of Drp1 decreased autophagy activation, suggesting that mitochondrial fission is involved in Phen-mediated mitophagy. Thus, our results demonstrate that the disruption of mitochondrial dynamics and mitochondrial dysfunctions provokes mitophagy in Phen-treated cells."xsd:string |
| http://purl.uniprot.org/citations/23123158 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2012.10.035"xsd:string |
| http://purl.uniprot.org/citations/23123158 | http://purl.uniprot.org/core/author | "Kim J.H."xsd:string |
| http://purl.uniprot.org/citations/23123158 | http://purl.uniprot.org/core/author | "Shin J.H."xsd:string |
| http://purl.uniprot.org/citations/23123158 | http://purl.uniprot.org/core/author | "Park S.J."xsd:string |
| http://purl.uniprot.org/citations/23123158 | http://purl.uniprot.org/core/author | "Kim E.S."xsd:string |
| http://purl.uniprot.org/citations/23123158 | http://purl.uniprot.org/core/author | "Kim J.C."xsd:string |
| http://purl.uniprot.org/citations/23123158 | http://purl.uniprot.org/core/author | "Cho D.H."xsd:string |
| http://purl.uniprot.org/citations/23123158 | http://purl.uniprot.org/core/author | "Jo Y.K."xsd:string |
| http://purl.uniprot.org/citations/23123158 | http://purl.uniprot.org/core/author | "Hwang J.J."xsd:string |
| http://purl.uniprot.org/citations/23123158 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23123158 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/23123158 | http://purl.uniprot.org/core/pages | "4303-4310"xsd:string |
| http://purl.uniprot.org/citations/23123158 | http://purl.uniprot.org/core/title | "Mitochondrial fragmentation caused by phenanthroline promotes mitophagy."xsd:string |
| http://purl.uniprot.org/citations/23123158 | http://purl.uniprot.org/core/volume | "586"xsd:string |
| http://purl.uniprot.org/citations/23123158 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23123158 |
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