| http://purl.uniprot.org/citations/23123404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23123404 | http://www.w3.org/2000/01/rdf-schema#comment | "The ubiquitous mammalian extracellular matrix glycosaminoglycan hyaluronan (HA) plays a pivotal role in the regulation of cell phenotype in fibrosis and scarring. Transforming growth factor-beta 1 (TGF-β1) and interleukin-1 beta (IL-1β) up-regulate hyaluronan synthase (HAS) 1 and HAS2 in dermal fibroblasts and renal proximal tubular epithelial cells, and subsequent HA synthesis regulates cell phenotype. In the present study, we investigated the mechanism of HAS1 transcriptional up-regulation in response to these cytokines. We used 5'-rapid amplification of cDNA ends analysis to identify the 5' end of HAS1 transcripts, resulting in an increase of 26 nucleotides to the HAS1 exon 1 sequence of reference sequence NM_001523. Constitutive luciferase activity of upstream DNA sequences was shown in luciferase reporter assays, but our reporter vector signals were refractory to the addition of TGF-β1 and IL-1β. Using siRNAs to knockdown transcription factor mRNAs, we showed that TGF-β1 up-regulation of HAS1 transcription was mediated via Smad3 but not Smad2, while HAS1 induction by IL-1β was Sp3, not Sp1, dependent."xsd:string |
| http://purl.uniprot.org/citations/23123404 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.matbio.2012.10.002"xsd:string |
| http://purl.uniprot.org/citations/23123404 | http://purl.uniprot.org/core/author | "Chen L."xsd:string |
| http://purl.uniprot.org/citations/23123404 | http://purl.uniprot.org/core/author | "Martin J."xsd:string |
| http://purl.uniprot.org/citations/23123404 | http://purl.uniprot.org/core/author | "Thomas D.W."xsd:string |
| http://purl.uniprot.org/citations/23123404 | http://purl.uniprot.org/core/author | "Bowen T."xsd:string |
| http://purl.uniprot.org/citations/23123404 | http://purl.uniprot.org/core/author | "Phillips A.O."xsd:string |
| http://purl.uniprot.org/citations/23123404 | http://purl.uniprot.org/core/author | "Luo D.D."xsd:string |
| http://purl.uniprot.org/citations/23123404 | http://purl.uniprot.org/core/author | "Michael D.R."xsd:string |
| http://purl.uniprot.org/citations/23123404 | http://purl.uniprot.org/core/author | "Neville R.D."xsd:string |
| http://purl.uniprot.org/citations/23123404 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23123404 | http://purl.uniprot.org/core/name | "Matrix Biol"xsd:string |
| http://purl.uniprot.org/citations/23123404 | http://purl.uniprot.org/core/pages | "373-379"xsd:string |
| http://purl.uniprot.org/citations/23123404 | http://purl.uniprot.org/core/title | "Identification and analysis of the human hyaluronan synthase 1 gene promoter reveals Smad3- and Sp3-mediated transcriptional induction."xsd:string |
| http://purl.uniprot.org/citations/23123404 | http://purl.uniprot.org/core/volume | "31"xsd:string |
| http://purl.uniprot.org/citations/23123404 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23123404 |
| http://purl.uniprot.org/citations/23123404 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23123404 |
| http://purl.uniprot.org/uniprot/#_D2N2G5-mappedCitation-23123404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23123404 |
| http://purl.uniprot.org/uniprot/#_G3V1S7-mappedCitation-23123404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23123404 |
| http://purl.uniprot.org/uniprot/#_Q4VHE4-mappedCitation-23123404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23123404 |
| http://purl.uniprot.org/uniprot/#_Q4VHE5-mappedCitation-23123404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23123404 |
| http://purl.uniprot.org/uniprot/#_Q4VHE6-mappedCitation-23123404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23123404 |
| http://purl.uniprot.org/uniprot/#_Q8IYH3-mappedCitation-23123404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23123404 |
| http://purl.uniprot.org/uniprot/#_Q92839-mappedCitation-23123404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23123404 |