http://purl.uniprot.org/citations/23124547 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/23124547 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundMelanoma-associated antigen-A4 (MAGE-A4) is one of the candidates for a target of immunotherapy and is expressed in non-small cell lung cancer (NSCLC). However, tumors sometimes lose human leukocyte antigen (HLA) class I expression, and tumor-specific T cells cannot eliminate the tumor with loss of HLA. However, the relationship between MAGE-A4 expression and HLA loss has remained unclear.MethodsAmong 363 NSCLC patients who consecutively underwent curative surgery, 187 cases whose material could be analyzed were reviewed. The expression of HLA class I molecules was assessed by immunohistochemical staining. The expression of MAGE-A4 was analyzed by RT-PCR.ResultsSeventy-seven tumors expressed HLA normally; however, 110 tumors lost HLA. The proportion of patients with a smoking habit and expressing the MAGE-A4 gene in patients with HLA loss was higher than those with HLA expression (p = 0.04 and 0.028, respectively). Five-year overall survival (OS) rate in the patients expressing MAGE-A4 but with loss of HLA was 52.4 %, and OS was significantly poorer than their counterparts (74.0 %, p = 0.036). Multivariate analysis indicated that advanced stage or history of smoking and HLA loss was an independently poor prognostic predictor of OS in NSCLC (p < 0.01 and p = 0.04, respectively).ConclusionHLA class I loss in NSCLC was related to smoking history and MAGE-A4 expression of tumors. HLA class I loss in smokers or patients with the MAGE-A4 gene was a prognostic factors in NSCLC."xsd:string |
http://purl.uniprot.org/citations/23124547 | http://purl.org/dc/terms/identifier | "doi:10.1007/s10147-012-0491-8"xsd:string |
http://purl.uniprot.org/citations/23124547 | http://purl.uniprot.org/core/author | "Baba T."xsd:string |
http://purl.uniprot.org/citations/23124547 | http://purl.uniprot.org/core/author | "Kuroda K."xsd:string |
http://purl.uniprot.org/citations/23124547 | http://purl.uniprot.org/core/author | "Ichiki Y."xsd:string |
http://purl.uniprot.org/citations/23124547 | http://purl.uniprot.org/core/author | "Shigematsu Y."xsd:string |
http://purl.uniprot.org/citations/23124547 | http://purl.uniprot.org/core/author | "Tanaka F."xsd:string |
http://purl.uniprot.org/citations/23124547 | http://purl.uniprot.org/core/author | "Shiota H."xsd:string |
http://purl.uniprot.org/citations/23124547 | http://purl.uniprot.org/core/author | "Hanagiri T."xsd:string |
http://purl.uniprot.org/citations/23124547 | http://purl.uniprot.org/core/author | "Uramoto H."xsd:string |
http://purl.uniprot.org/citations/23124547 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
http://purl.uniprot.org/citations/23124547 | http://purl.uniprot.org/core/name | "Int J Clin Oncol"xsd:string |
http://purl.uniprot.org/citations/23124547 | http://purl.uniprot.org/core/pages | "997-1004"xsd:string |
http://purl.uniprot.org/citations/23124547 | http://purl.uniprot.org/core/title | "Clinical significance of human leukocyte antigen loss and melanoma-associated antigen 4 expression in smokers of non-small cell lung cancer patients."xsd:string |
http://purl.uniprot.org/citations/23124547 | http://purl.uniprot.org/core/volume | "18"xsd:string |
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