| http://purl.uniprot.org/citations/23126280 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23126280 | http://www.w3.org/2000/01/rdf-schema#comment | "Cytoskeleton remodelling is a prerequisite step for the morphological transition from preadipocytes to mature adipocytes. Although microtubules play a pivotal role in organizing cellular structure, regulation of microtubule dynamics during adipogenesis remains unclear. In the present paper we show that acetylation of α-tubulin is up-regulated during adipogenesis, and adipocyte development is dependent on α-tubulin acetylation, as expression of an acetylation-resistant α-tubulin mutant significantly inhibits adipogenesis. Moreover, acetylation of α-tubulin is under the control of the acetyltransferase MEC-17 and deacetylases SIRT2 (Sirtuin 2) and HDAC6 (histone deacetylase 6). Adipocyte development is inhibited in MEC-17-knockdown cells, but enhanced in MEC-17-overexpressing cells. Finally, we show that katanin, a microtubule-severing protein with enhanced activity on acetylated α-tubulin, is actively involved in adipogenesis. We propose that co-ordinated up-regulation of α-tubulin acetylation initiates cytoskeleton remodelling by promoting α-tubulin severing by katanin which, in turn, allows expansion of lipid droplets and accelerates the morphological transition toward mature adipocytes."xsd:string |
| http://purl.uniprot.org/citations/23126280 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj20121121"xsd:string |
| http://purl.uniprot.org/citations/23126280 | http://purl.uniprot.org/core/author | "Guo X."xsd:string |
| http://purl.uniprot.org/citations/23126280 | http://purl.uniprot.org/core/author | "Han W."xsd:string |
| http://purl.uniprot.org/citations/23126280 | http://purl.uniprot.org/core/author | "Yang W."xsd:string |
| http://purl.uniprot.org/citations/23126280 | http://purl.uniprot.org/core/author | "Xu F."xsd:string |
| http://purl.uniprot.org/citations/23126280 | http://purl.uniprot.org/core/author | "Baas P.W."xsd:string |
| http://purl.uniprot.org/citations/23126280 | http://purl.uniprot.org/core/author | "Sugii S."xsd:string |
| http://purl.uniprot.org/citations/23126280 | http://purl.uniprot.org/core/author | "Radda G.K."xsd:string |
| http://purl.uniprot.org/citations/23126280 | http://purl.uniprot.org/core/author | "Thein S."xsd:string |
| http://purl.uniprot.org/citations/23126280 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23126280 | http://purl.uniprot.org/core/name | "Biochem J"xsd:string |
| http://purl.uniprot.org/citations/23126280 | http://purl.uniprot.org/core/pages | "605-612"xsd:string |
| http://purl.uniprot.org/citations/23126280 | http://purl.uniprot.org/core/title | "Regulation of adipogenesis by cytoskeleton remodelling is facilitated by acetyltransferase MEC-17-dependent acetylation of alpha-tubulin."xsd:string |
| http://purl.uniprot.org/citations/23126280 | http://purl.uniprot.org/core/volume | "449"xsd:string |
| http://purl.uniprot.org/citations/23126280 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23126280 |
| http://purl.uniprot.org/citations/23126280 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23126280 |
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