| http://purl.uniprot.org/citations/23129634 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23129634 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23129634 | http://www.w3.org/2000/01/rdf-schema#comment | "Evolutionary biologists have postulated that several fitness advantages may be conferred by the maintenance of duplicate genes, including environmental adaptation resulting from differential regulation. We examined the expression and physiological contributions of two redundant operons in the adaptable bacterium Pseudomonas aeruginosa PA14. These operons, phzA1-G1 (phz1) and phzA2-G2 (phz2), encode nearly identical sets of proteins that catalyze the synthesis of phenazine-1-carboxylic acid, the precursor for several phenazine derivatives. Phenazines perform diverse roles in P. aeruginosa physiology and act as virulence factors during opportunistic infections of plant and animal hosts. Although reports have indicated that phz1 is regulated by the Pseudomonas quinolone signal, factors controlling phz2 expression have not been identified, and the relative contributions of these redundant operons to phenazine biosynthesis have not been evaluated. We found that in liquid cultures, phz1 was expressed at higher levels than phz2, although phz2 showed a greater contribution to phenazine production. In colony biofilms, phz2 was expressed at high levels, whereas phz1 expression was not detectable, and phz2 was responsible for virtually all phenazine production. Analysis of mutants defective in quinolone signal synthesis revealed a critical role for 4-hydroxy-2-heptylquinoline in phz2 induction. Finally, deletion of phz2, but not of phz1, decreased lung colonization in a murine model of infection. These results suggest that differential regulation of the redundant phz operons allows P. aeruginosa to adapt to diverse environments."xsd:string |
| http://purl.uniprot.org/citations/23129634 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1213901109"xsd:string |
| http://purl.uniprot.org/citations/23129634 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1213901109"xsd:string |
| http://purl.uniprot.org/citations/23129634 | http://purl.uniprot.org/core/author | "Hernandez A."xsd:string |
| http://purl.uniprot.org/citations/23129634 | http://purl.uniprot.org/core/author | "Hernandez A."xsd:string |
| http://purl.uniprot.org/citations/23129634 | http://purl.uniprot.org/core/author | "Cohen T.S."xsd:string |
| http://purl.uniprot.org/citations/23129634 | http://purl.uniprot.org/core/author | "Cohen T.S."xsd:string |
| http://purl.uniprot.org/citations/23129634 | http://purl.uniprot.org/core/author | "Dietrich L.E."xsd:string |
| http://purl.uniprot.org/citations/23129634 | http://purl.uniprot.org/core/author | "Dietrich L.E."xsd:string |
| http://purl.uniprot.org/citations/23129634 | http://purl.uniprot.org/core/author | "Price-Whelan A."xsd:string |
| http://purl.uniprot.org/citations/23129634 | http://purl.uniprot.org/core/author | "Price-Whelan A."xsd:string |
| http://purl.uniprot.org/citations/23129634 | http://purl.uniprot.org/core/author | "Prince A.S."xsd:string |
| http://purl.uniprot.org/citations/23129634 | http://purl.uniprot.org/core/author | "Prince A.S."xsd:string |
| http://purl.uniprot.org/citations/23129634 | http://purl.uniprot.org/core/author | "Recinos D.A."xsd:string |
| http://purl.uniprot.org/citations/23129634 | http://purl.uniprot.org/core/author | "Recinos D.A."xsd:string |
| http://purl.uniprot.org/citations/23129634 | http://purl.uniprot.org/core/author | "Sakhtah H."xsd:string |
| http://purl.uniprot.org/citations/23129634 | http://purl.uniprot.org/core/author | "Sakhtah H."xsd:string |
| http://purl.uniprot.org/citations/23129634 | http://purl.uniprot.org/core/author | "Sekedat M.D."xsd:string |
| http://purl.uniprot.org/citations/23129634 | http://purl.uniprot.org/core/author | "Sekedat M.D."xsd:string |
| http://purl.uniprot.org/citations/23129634 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23129634 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23129634 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/23129634 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |