| http://purl.uniprot.org/citations/23129809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23129809 | http://www.w3.org/2000/01/rdf-schema#comment | "Every known SWI/SNF chromatin-remodeling complex incorporates an ARID DNA binding domain-containing subunit. Despite being a ubiquitous component of the complex, physiological roles for this domain remain undefined. Here, we show that disruption of ARID1a-DNA binding in mice results in embryonic lethality, with mutant embryos manifesting prominent defects in the heart and extraembryonic vasculature. The DNA binding-defective mutant ARID1a subunit is stably expressed and capable of assembling into a SWI/SNF complex with core catalytic properties, but nucleosome substrate binding and promoter occupancy by ARID1a-containing SWI/SNF complexes (BAF-A) are impaired. Depletion of ARID domain-dependent, BAF-A associations at THROMBOSPONDIN 1 (THBS1) led to the concomitant upregulation of this SWI/SNF target gene. Using a THBS1 promoter-reporter gene, we further show that BAF-A directly regulates THBS1 promoter activity in an ARID domain-dependent manner. Our data not only demonstrate that ARID1a-DNA interactions are physiologically relevant in higher eukaryotes but also indicate that these interactions facilitate SWI/SNF binding to target sites in vivo. These findings support the model wherein cooperative interactions among intrinsic subunit-chromatin interaction domains and sequence-specific transcription factors drive SWI/SNF recruitment."xsd:string |
| http://purl.uniprot.org/citations/23129809 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.01008-12"xsd:string |
| http://purl.uniprot.org/citations/23129809 | http://purl.uniprot.org/core/author | "Magnuson T."xsd:string |
| http://purl.uniprot.org/citations/23129809 | http://purl.uniprot.org/core/author | "Patterson C."xsd:string |
| http://purl.uniprot.org/citations/23129809 | http://purl.uniprot.org/core/author | "Schisler J.C."xsd:string |
| http://purl.uniprot.org/citations/23129809 | http://purl.uniprot.org/core/author | "Brennan J."xsd:string |
| http://purl.uniprot.org/citations/23129809 | http://purl.uniprot.org/core/author | "Chandler R.L."xsd:string |
| http://purl.uniprot.org/citations/23129809 | http://purl.uniprot.org/core/author | "Serber D."xsd:string |
| http://purl.uniprot.org/citations/23129809 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23129809 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/23129809 | http://purl.uniprot.org/core/pages | "265-280"xsd:string |
| http://purl.uniprot.org/citations/23129809 | http://purl.uniprot.org/core/title | "ARID1a-DNA interactions are required for promoter occupancy by SWI/SNF."xsd:string |
| http://purl.uniprot.org/citations/23129809 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/23129809 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23129809 |
| http://purl.uniprot.org/citations/23129809 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23129809 |
| http://purl.uniprot.org/uniprot/O14497#attribution-757C8585B6CD238F78B7DE483D0BB41F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23129809 |
| http://purl.uniprot.org/uniprot/A2BH40#attribution-1C925D14735709709C4320AC86AD4439 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23129809 |
| http://purl.uniprot.org/uniprot/A2BH40#attribution-757C8585B6CD238F78B7DE483D0BB41F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23129809 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SVB2-mappedCitation-23129809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23129809 |
| http://purl.uniprot.org/uniprot/#_E9QAB8-mappedCitation-23129809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23129809 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J170-mappedCitation-23129809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23129809 |
| http://purl.uniprot.org/uniprot/#_D3YZ83-mappedCitation-23129809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23129809 |
| http://purl.uniprot.org/uniprot/#_E9Q6R4-mappedCitation-23129809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23129809 |
| http://purl.uniprot.org/uniprot/#_E9Q7E2-mappedCitation-23129809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23129809 |