| http://purl.uniprot.org/citations/23133401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23133401 | http://www.w3.org/2000/01/rdf-schema#comment | "The Arabidopsis fruit mainly consists of a mature ovary that shows three well defined territories that are pattern elements along the mediolateral axis: the replum, located at the medial plane of the flower, and the valve and the valve margin, both of lateral nature. JAG/FIL activity, which includes the combined functions of JAGGED (JAG), FILAMENTOUS FLOWER (FIL), and YABBY3 (YAB3), contributes to the formation of the two lateral pattern elements, whereas the cooperating genes BREVIPEDICELLUS (BP) and REPLUMLESS (RPL) promote replum development. A recent model to explain pattern formation along the mediolateral axis hypothesizes that JAG/FIL activity and BP/RPL function as antagonistic lateral and medial factors, respectively, which tend to repress each other. In this work, we demonstrate the existence of mutual exclusion mechanisms between both kinds of factors, and how this determines the formation and size of the three territories. Medial factors autonomously constrain lateral factors so that they only express outside the replum, and lateral factors negatively regulate the medially expressed BP gene in a non-autonomous fashion to ensure correct replum development. We also have found that ASYMMETRIC LEAVES1 (AS1), previously shown to repress BP both in leaves and ovaries, collaborates with JAG/FIL activity, preventing its repression by BP and showing synergistic interactions with JAG/FIL activity genes. Therefore AS gene function (the function of the interacting genes AS1 and AS2) has been incorporated in the model as a new lateral factor. Our model of antagonistic factors provides explanation for mutant fruit phenotypes in Arabidopsis and also may help to understand natural variation of fruit shape in Brassicaceae and other species, since subtle changes in gene expression may cause conspicuous changes in the size of the different tissue types."xsd:string |
| http://purl.uniprot.org/citations/23133401 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1003020"xsd:string |
| http://purl.uniprot.org/citations/23133401 | http://purl.uniprot.org/core/author | "Yanofsky M.F."xsd:string |
| http://purl.uniprot.org/citations/23133401 | http://purl.uniprot.org/core/author | "Martinez-Laborda A."xsd:string |
| http://purl.uniprot.org/citations/23133401 | http://purl.uniprot.org/core/author | "Ripoll J.J."xsd:string |
| http://purl.uniprot.org/citations/23133401 | http://purl.uniprot.org/core/author | "Vera A."xsd:string |
| http://purl.uniprot.org/citations/23133401 | http://purl.uniprot.org/core/author | "Gonzalez-Reig S."xsd:string |
| http://purl.uniprot.org/citations/23133401 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23133401 | http://purl.uniprot.org/core/name | "PLoS Genet"xsd:string |
| http://purl.uniprot.org/citations/23133401 | http://purl.uniprot.org/core/pages | "e1003020"xsd:string |
| http://purl.uniprot.org/citations/23133401 | http://purl.uniprot.org/core/title | "Antagonistic gene activities determine the formation of pattern elements along the mediolateral axis of the Arabidopsis fruit."xsd:string |
| http://purl.uniprot.org/citations/23133401 | http://purl.uniprot.org/core/volume | "8"xsd:string |
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