| http://purl.uniprot.org/citations/23133618 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23133618 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23133618 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23133618 | http://www.w3.org/2000/01/rdf-schema#comment | "In May of 2011, an enteroaggregative Escherichia coli O104:H4 strain that had acquired a Shiga toxin 2-converting phage caused a large outbreak of bloody diarrhea in Europe which was notable for its high prevalence of hemolytic uremic syndrome cases. Several studies have described the genomic inventory and phylogenies of strains associated with the outbreak and a collection of historical E. coli O104:H4 isolates using draft genome assemblies. We present the complete, closed genome sequences of an isolate from the 2011 outbreak (2011C-3493) and two isolates from cases of bloody diarrhea that occurred in the Republic of Georgia in 2009 (2009EL-2050 and 2009EL-2071). Comparative genome analysis indicates that, while the Georgian strains are the nearest neighbors to the 2011 outbreak isolates sequenced to date, structural and nucleotide-level differences are evident in the Stx2 phage genomes, the mer/tet antibiotic resistance island, and in the prophage and plasmid profiles of the strains, including a previously undescribed plasmid with homology to the pMT virulence plasmid of Yersinia pestis. In addition, multiphenotype analysis showed that 2009EL-2071 possessed higher resistance to polymyxin and membrane-disrupting agents. Finally, we show evidence by electron microscopy of the presence of a common phage morphotype among the European and Georgian strains and a second phage morphotype among the Georgian strains. The presence of at least two stx2 phage genotypes in host genetic backgrounds that may derive from a recent common ancestor of the 2011 outbreak isolates indicates that the emergence of stx2 phage-containing E. coli O104:H4 strains probably occurred more than once, or that the current outbreak isolates may be the result of a recent transfer of a new stx2 phage element into a pre-existing stx2-positive genetic background."xsd:string |
| http://purl.uniprot.org/citations/23133618 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0048228"xsd:string |
| http://purl.uniprot.org/citations/23133618 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0048228"xsd:string |
| http://purl.uniprot.org/citations/23133618 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0048228"xsd:string |
| http://purl.uniprot.org/citations/23133618 | http://purl.uniprot.org/core/author | "Chertkov O."xsd:string |
| http://purl.uniprot.org/citations/23133618 | http://purl.uniprot.org/core/author | "Chertkov O."xsd:string |
| http://purl.uniprot.org/citations/23133618 | http://purl.uniprot.org/core/author | "Chertkov O."xsd:string |
| http://purl.uniprot.org/citations/23133618 | http://purl.uniprot.org/core/author | "Detter J.C."xsd:string |
| http://purl.uniprot.org/citations/23133618 | http://purl.uniprot.org/core/author | "Detter J.C."xsd:string |
| http://purl.uniprot.org/citations/23133618 | http://purl.uniprot.org/core/author | "Detter J.C."xsd:string |
| http://purl.uniprot.org/citations/23133618 | http://purl.uniprot.org/core/author | "Ahmed S.A."xsd:string |
| http://purl.uniprot.org/citations/23133618 | http://purl.uniprot.org/core/author | "Ahmed S.A."xsd:string |
| http://purl.uniprot.org/citations/23133618 | http://purl.uniprot.org/core/author | "Ahmed S.A."xsd:string |
| http://purl.uniprot.org/citations/23133618 | http://purl.uniprot.org/core/author | "Chain P.S."xsd:string |
| http://purl.uniprot.org/citations/23133618 | http://purl.uniprot.org/core/author | "Chain P.S."xsd:string |
| http://purl.uniprot.org/citations/23133618 | http://purl.uniprot.org/core/author | "Chain P.S."xsd:string |
| http://purl.uniprot.org/citations/23133618 | http://purl.uniprot.org/core/author | "Davenport K."xsd:string |
| http://purl.uniprot.org/citations/23133618 | http://purl.uniprot.org/core/author | "Davenport K."xsd:string |
| http://purl.uniprot.org/citations/23133618 | http://purl.uniprot.org/core/author | "Davenport K."xsd:string |
| http://purl.uniprot.org/citations/23133618 | http://purl.uniprot.org/core/author | "Johnson S."xsd:string |
| http://purl.uniprot.org/citations/23133618 | http://purl.uniprot.org/core/author | "Johnson S."xsd:string |
| http://purl.uniprot.org/citations/23133618 | http://purl.uniprot.org/core/author | "Johnson S."xsd:string |