| http://purl.uniprot.org/citations/23144170 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23144170 | http://www.w3.org/2000/01/rdf-schema#comment | "Immunoglobulin class switching from IgM to IgG in response to peptides is generally T cell-dependent and vaccination in T cell-deficient individuals is inefficient. We show that a vaccine consisting of a dense array of peptides on liposomes induced peptide-specific IgG responses totally independent of T-cell help. Independency was confirmed in mice lacking T cells and in mice deficient for MHC class II, CD40L, and CD28. The IgG titers were high, long-lived, and comparable with titers obtained in wild-type animals, and the antibody response was associated with germinal center formation, expression of activation-induced cytidine deaminase, and affinity maturation. The T cell-independent (TI) IgG response was strictly dependent on ligation of TLR4 receptors on B cells, and concomitant TLR4 and cognate B-cell receptor stimulation was required on a single-cell level. Surprisingly, the IgG class switch was mediated by TIR-domain-containing adapter inducing interferon-β (TRIF), but not by MyD88. This study demonstrates that peptides can induce TI isotype switching when antigen and TLR ligand are assembled and appropriately presented directly to B lymphocytes. A TI vaccine could enable efficient prophylactic and therapeutic vaccination of patients with T-cell deficiencies and find application in diseases where induction of T-cell responses contraindicates vaccination, for example, in Alzheimer disease."xsd:string |
| http://purl.uniprot.org/citations/23144170 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2012-02-413831"xsd:string |
| http://purl.uniprot.org/citations/23144170 | http://purl.uniprot.org/core/author | "Pfeifer A."xsd:string |
| http://purl.uniprot.org/citations/23144170 | http://purl.uniprot.org/core/author | "Vukicevic M."xsd:string |
| http://purl.uniprot.org/citations/23144170 | http://purl.uniprot.org/core/author | "Reis P."xsd:string |
| http://purl.uniprot.org/citations/23144170 | http://purl.uniprot.org/core/author | "Chuard N."xsd:string |
| http://purl.uniprot.org/citations/23144170 | http://purl.uniprot.org/core/author | "Madani R."xsd:string |
| http://purl.uniprot.org/citations/23144170 | http://purl.uniprot.org/core/author | "Silva A.B."xsd:string |
| http://purl.uniprot.org/citations/23144170 | http://purl.uniprot.org/core/author | "Muhs A."xsd:string |
| http://purl.uniprot.org/citations/23144170 | http://purl.uniprot.org/core/author | "Pihlgren M."xsd:string |
| http://purl.uniprot.org/citations/23144170 | http://purl.uniprot.org/core/author | "Piorkowska K."xsd:string |
| http://purl.uniprot.org/citations/23144170 | http://purl.uniprot.org/core/author | "Hickman D.T."xsd:string |
| http://purl.uniprot.org/citations/23144170 | http://purl.uniprot.org/core/author | "Kundig T.M."xsd:string |
| http://purl.uniprot.org/citations/23144170 | http://purl.uniprot.org/core/author | "Gafner V."xsd:string |
| http://purl.uniprot.org/citations/23144170 | http://purl.uniprot.org/core/author | "Waeckerle-Men Y."xsd:string |
| http://purl.uniprot.org/citations/23144170 | http://purl.uniprot.org/core/author | "Johansen P."xsd:string |
| http://purl.uniprot.org/citations/23144170 | http://purl.uniprot.org/core/author | "Buccarello A.L."xsd:string |
| http://purl.uniprot.org/citations/23144170 | http://purl.uniprot.org/core/author | "Fettelschoss A."xsd:string |
| http://purl.uniprot.org/citations/23144170 | http://purl.uniprot.org/core/author | "Giriens V."xsd:string |
| http://purl.uniprot.org/citations/23144170 | http://purl.uniprot.org/core/author | "Lopez-Deber M.P."xsd:string |
| http://purl.uniprot.org/citations/23144170 | http://purl.uniprot.org/core/author | "Ndao D.M."xsd:string |
| http://purl.uniprot.org/citations/23144170 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23144170 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/23144170 | http://purl.uniprot.org/core/pages | "85-94"xsd:string |