| http://purl.uniprot.org/citations/23145148 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23145148 | http://www.w3.org/2000/01/rdf-schema#comment | "Regulation of poly(ADP-ribose) (PAR) synthesis and turnover is critical to determining cell fate after genotoxic stress. Hyperactivation of PAR synthesis by poly(ADP-ribose) polymerase-1 (PARP-1) occurs when cells deficient in DNA repair are exposed to genotoxic agents; however, the function of this hyperactivation has not been adequately explained. Here, we examine PAR synthesis in mouse fibroblasts deficient in the base excision repair enzyme DNA polymerase β (pol β). The extent and duration of PARP-1 activation was measured after exposure to either the DNA alkylating agent, methyl methanesulfonate (MMS), or to low energy laser-induced DNA damage. There was strong DNA damage-induced hyperactivation of PARP-1 in pol β nullcells, but not in wild-type cells. In the case of MMS treatment, PAR synthesis did not lead to cell death in the pol β null cells, but instead resulted in increased PARylation of the nonhomologous end-joining (NHEJ) protein Ku70 and increased association of Ku70 with PARP-1. Inhibition of the NHEJ factor DNA-PK, under conditions of MMS-induced PARP-1 hyperactivation, enhanced necrotic cell death. These data suggest that PARP-1 hyperactivation is a protective mechanism triggering the classical-NHEJ DNA repair pathway when the primary alkylated base damage repair pathway is compromised."xsd:string |
| http://purl.uniprot.org/citations/23145148 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0049301"xsd:string |
| http://purl.uniprot.org/citations/23145148 | http://purl.uniprot.org/core/author | "Wilson S.H."xsd:string |
| http://purl.uniprot.org/citations/23145148 | http://purl.uniprot.org/core/author | "Kedar P.S."xsd:string |
| http://purl.uniprot.org/citations/23145148 | http://purl.uniprot.org/core/author | "Horton J.K."xsd:string |
| http://purl.uniprot.org/citations/23145148 | http://purl.uniprot.org/core/author | "Gassman N.R."xsd:string |
| http://purl.uniprot.org/citations/23145148 | http://purl.uniprot.org/core/author | "Stefanick D.F."xsd:string |
| http://purl.uniprot.org/citations/23145148 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23145148 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/23145148 | http://purl.uniprot.org/core/pages | "e49301"xsd:string |
| http://purl.uniprot.org/citations/23145148 | http://purl.uniprot.org/core/title | "Hyperactivation of PARP triggers nonhomologous end-joining in repair-deficient mouse fibroblasts."xsd:string |
| http://purl.uniprot.org/citations/23145148 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/23145148 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23145148 |
| http://purl.uniprot.org/citations/23145148 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23145148 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YVX0-mappedCitation-23145148 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23145148 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YX03-mappedCitation-23145148 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23145148 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YY63-mappedCitation-23145148 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23145148 |
| http://purl.uniprot.org/uniprot/#_P11103-mappedCitation-23145148 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23145148 |
| http://purl.uniprot.org/uniprot/#_Q3U868-mappedCitation-23145148 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23145148 |
| http://purl.uniprot.org/uniprot/#_Q3TX36-mappedCitation-23145148 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23145148 |
| http://purl.uniprot.org/uniprot/#_Q921K2-mappedCitation-23145148 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23145148 |
| http://purl.uniprot.org/uniprot/#_Q3UJ03-mappedCitation-23145148 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23145148 |
| http://purl.uniprot.org/uniprot/#_P97340-mappedCitation-23145148 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23145148 |
| http://purl.uniprot.org/uniprot/#_Q3TF18-mappedCitation-23145148 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23145148 |