| http://purl.uniprot.org/citations/23152542 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23152542 | http://www.w3.org/2000/01/rdf-schema#comment | "The C-terminus of CBFβ-SMMHC, the fusion protein produced by a chromosome 16 inversion in acute myeloid leukemia subtype M4Eo, contains domains for self-multimerization and transcriptional repression, both of which have been proposed to be important for leukemogenesis by CBFβ-SMMHC. To test the role of the fusion protein's C-terminus in vivo, we generated knock-in mice expressing a C-terminally truncated CBFβ-SMMHC (CBFβ-SMMHCΔC95). Embryos with a single copy of CBFβ-SMMHCΔC95 were viable and showed no defects in hematopoiesis, whereas embryos homozygous for the CBFβ-SMMHCΔC95 allele had hematopoietic defects and died in mid-gestation, similar to embryos with a single-copy of the full-length CBFβ-SMMHC. Importantly, unlike mice expressing full-length CBFβ-SMMHC, none of the mice expressing CBFβ-SMMHCΔC95 developed leukemia, even after treatment with a mutagen, although some of the older mice developed a nontransplantable myeloproliferative disease. Our data indicate that the CBFβ-SMMHC's C-terminus is essential to induce embryonic hematopoietic defects and leukemogenesis."xsd:string |
| http://purl.uniprot.org/citations/23152542 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2012-06-434688"xsd:string |
| http://purl.uniprot.org/citations/23152542 | http://purl.uniprot.org/core/author | "Zhao L."xsd:string |
| http://purl.uniprot.org/citations/23152542 | http://purl.uniprot.org/core/author | "Liu P.P."xsd:string |
| http://purl.uniprot.org/citations/23152542 | http://purl.uniprot.org/core/author | "Kamikubo Y."xsd:string |
| http://purl.uniprot.org/citations/23152542 | http://purl.uniprot.org/core/author | "Rivas C."xsd:string |
| http://purl.uniprot.org/citations/23152542 | http://purl.uniprot.org/core/author | "Garrett L.J."xsd:string |
| http://purl.uniprot.org/citations/23152542 | http://purl.uniprot.org/core/author | "Hyde R.K."xsd:string |
| http://purl.uniprot.org/citations/23152542 | http://purl.uniprot.org/core/author | "Alemu L."xsd:string |
| http://purl.uniprot.org/citations/23152542 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23152542 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/23152542 | http://purl.uniprot.org/core/pages | "638-642"xsd:string |
| http://purl.uniprot.org/citations/23152542 | http://purl.uniprot.org/core/title | "The C-terminus of CBFbeta-SMMHC is required to induce embryonic hematopoietic defects and leukemogenesis."xsd:string |
| http://purl.uniprot.org/citations/23152542 | http://purl.uniprot.org/core/volume | "121"xsd:string |
| http://purl.uniprot.org/citations/23152542 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23152542 |
| http://purl.uniprot.org/citations/23152542 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23152542 |
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