| http://purl.uniprot.org/citations/2315314 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2315314 | http://www.w3.org/2000/01/rdf-schema#comment | "We have purified and characterized active recombinant human bone morphogenetic protein (BMP) 2A. Implantation of the recombinant protein in rats showed that a single BMP can induce bone formation in vivo. A dose-response and time-course study using the rat ectopic bone formation assay revealed that implantation of 0.5-115 micrograms of partially purified recombinant human BMP-2A resulted in cartilage by day 7 and bone formation by day 14. The time at which bone formation occurred was dependent on the amount of BMP-2A implanted; at high doses bone formation could be observed at 5 days. The cartilage- and bone-inductive activity of the recombinant BMP-2A is histologically indistinguishable from that of bone extracts. Thus, recombinant BMP-2A has therapeutic potential to promote de novo bone formation in humans."xsd:string |
| http://purl.uniprot.org/citations/2315314 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.87.6.2220"xsd:string |
| http://purl.uniprot.org/citations/2315314 | http://purl.uniprot.org/core/author | "Harada T."xsd:string |
| http://purl.uniprot.org/citations/2315314 | http://purl.uniprot.org/core/author | "Rosen V."xsd:string |
| http://purl.uniprot.org/citations/2315314 | http://purl.uniprot.org/core/author | "Hewick R.M."xsd:string |
| http://purl.uniprot.org/citations/2315314 | http://purl.uniprot.org/core/author | "Wang E.A."xsd:string |
| http://purl.uniprot.org/citations/2315314 | http://purl.uniprot.org/core/author | "Bauduy M."xsd:string |
| http://purl.uniprot.org/citations/2315314 | http://purl.uniprot.org/core/author | "Cordes P."xsd:string |
| http://purl.uniprot.org/citations/2315314 | http://purl.uniprot.org/core/author | "D'Alessandro J.S."xsd:string |
| http://purl.uniprot.org/citations/2315314 | http://purl.uniprot.org/core/author | "Israel D.I."xsd:string |
| http://purl.uniprot.org/citations/2315314 | http://purl.uniprot.org/core/author | "Kerns K.M."xsd:string |
| http://purl.uniprot.org/citations/2315314 | http://purl.uniprot.org/core/author | "LaPan P."xsd:string |
| http://purl.uniprot.org/citations/2315314 | http://purl.uniprot.org/core/date | "1990"xsd:gYear |
| http://purl.uniprot.org/citations/2315314 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/2315314 | http://purl.uniprot.org/core/pages | "2220-2224"xsd:string |
| http://purl.uniprot.org/citations/2315314 | http://purl.uniprot.org/core/title | "Recombinant human bone morphogenetic protein induces bone formation."xsd:string |
| http://purl.uniprot.org/citations/2315314 | http://purl.uniprot.org/core/volume | "87"xsd:string |
| http://purl.uniprot.org/citations/2315314 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/2315314 |
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| http://purl.uniprot.org/uniprot/P12643#attribution-03D5A51036D615EB852A4CC705128487 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/2315314 |