| http://purl.uniprot.org/citations/23159318 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23159318 | http://www.w3.org/2000/01/rdf-schema#comment | "Synthesis of H1° histone, in the developing rat brain, is also regulated at post-transcriptional level. Regulation of RNA metabolism depends on a series of RNA-binding proteins (RBPs); therefore, we searched for H1° mRNA-interacting proteins. With this aim, we used in vitro transcribed, biotinylated H1° RNA as bait to isolate, by a chromatographic approach, proteins which interact with this mRNA, in the nuclei of brain cells. Abundant RBPs, such as heterogeneous nuclear ribonucleoprotein (hnRNP) K and hnRNP A1, and molecular chaperones (heat shock cognate 70, Hsc70) were identified by mass spectrometry. Western blot analysis also revealed the presence of cold shock domain-containing protein 2 (CSD-C2, also known as PIPPin), a brain-enriched RBP previously described in our laboratory. Co-immunoprecipitation assays were performed to investigate the possibility that identified proteins interact with each other and with other nuclear proteins. We found that hnRNP K interacts with both hnRNP A1 and Hsc70 whereas there is no interaction between hnRNP A1 and Hsc70. Moreover, CSD-C2 interacts with hnRNP A1, Y box-binding protein 1 (YB-1), and hnRNP K. We also have indications that CSD-C2 interacts with Hsc70. Overall, we have contributed to the molecular characterization of a ribonucleoprotein particle possibly controlling H1° histone expression in the brain."xsd:string |
| http://purl.uniprot.org/citations/23159318 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuroscience.2012.10.072"xsd:string |
| http://purl.uniprot.org/citations/23159318 | http://purl.uniprot.org/core/author | "Di Liegro I."xsd:string |
| http://purl.uniprot.org/citations/23159318 | http://purl.uniprot.org/core/author | "Di Liegro C.M."xsd:string |
| http://purl.uniprot.org/citations/23159318 | http://purl.uniprot.org/core/author | "Proia P."xsd:string |
| http://purl.uniprot.org/citations/23159318 | http://purl.uniprot.org/core/author | "Schiera G."xsd:string |
| http://purl.uniprot.org/citations/23159318 | http://purl.uniprot.org/core/author | "Saladino P."xsd:string |
| http://purl.uniprot.org/citations/23159318 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23159318 | http://purl.uniprot.org/core/name | "Neuroscience"xsd:string |
| http://purl.uniprot.org/citations/23159318 | http://purl.uniprot.org/core/pages | "71-76"xsd:string |
| http://purl.uniprot.org/citations/23159318 | http://purl.uniprot.org/core/title | "Identification in the rat brain of a set of nuclear proteins interacting with H1° mRNA."xsd:string |
| http://purl.uniprot.org/citations/23159318 | http://purl.uniprot.org/core/volume | "229"xsd:string |
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