| http://purl.uniprot.org/citations/23159614 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23159614 | http://www.w3.org/2000/01/rdf-schema#comment | "Drugs designed specifically to activate liver X receptors (LXRs) have beneficial effects on lowering cholesterol metabolism and inflammation but unfortunately lead to severe hepatic steatosis. The transcription factor CCAAT/enhancer binding protein beta (C/EBPβ) is an important regulator of liver gene expression but little is known about its involvement in LXR-based steatosis and cholesterol metabolism. The present study investigated the role of C/EBPβ expression in LXR agonist (T0901317)-mediated alteration of hepatic triglyceride (TG) and lipogenesis in mice. C/EBPβ deletion in mice prevented LXR agonist-mediated induction of lipogenic gene expression in liver in conjunction with significant reduction of liver TG accumulation. Surprisingly, C/EBPβ(-/-) mice showed a major increase in liver mitochondrial electron chain function compared to WT mice. Furthermore, LXR activation in C/EBPβ(-/-) mice increased the expression of liver ATP-binding cassette transporter ABCG1, a gene implicated in cholesterol efflux and reducing blood levels of total and LDL-cholesterol. Together, these findings establish a central role for C/EBPβ in the LXR-mediated steatosis and mitochondrial function, without impairing the influence of LXR activation on lowering LDL and increasing HDL-cholesterol. Inactivation of C/EBPβ might therefore be an important therapeutic strategy to prevent LXR activation-mediated adverse effects on liver TG metabolism without disrupting its beneficial effects on cholesterol metabolism."xsd:string |
| http://purl.uniprot.org/citations/23159614 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2012.11.027"xsd:string |
| http://purl.uniprot.org/citations/23159614 | http://purl.uniprot.org/core/author | "Miyazaki M."xsd:string |
| http://purl.uniprot.org/citations/23159614 | http://purl.uniprot.org/core/author | "Rahman S.M."xsd:string |
| http://purl.uniprot.org/citations/23159614 | http://purl.uniprot.org/core/author | "Choudhury M."xsd:string |
| http://purl.uniprot.org/citations/23159614 | http://purl.uniprot.org/core/author | "Janssen R.C."xsd:string |
| http://purl.uniprot.org/citations/23159614 | http://purl.uniprot.org/core/author | "Friedman J.E."xsd:string |
| http://purl.uniprot.org/citations/23159614 | http://purl.uniprot.org/core/author | "Baquero K.C."xsd:string |
| http://purl.uniprot.org/citations/23159614 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23159614 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/23159614 | http://purl.uniprot.org/core/pages | "336-339"xsd:string |
| http://purl.uniprot.org/citations/23159614 | http://purl.uniprot.org/core/title | "CCAAT/enhancer binding protein beta deletion increases mitochondrial function and protects mice from LXR-induced hepatic steatosis."xsd:string |
| http://purl.uniprot.org/citations/23159614 | http://purl.uniprot.org/core/volume | "430"xsd:string |
| http://purl.uniprot.org/citations/23159614 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23159614 |
| http://purl.uniprot.org/citations/23159614 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23159614 |
| http://purl.uniprot.org/uniprot/#_P28033-mappedCitation-23159614 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23159614 |
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| http://purl.uniprot.org/uniprot/O70192 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23159614 |