| http://purl.uniprot.org/citations/23159740 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23159740 | http://www.w3.org/2000/01/rdf-schema#comment | "Vascular endothelial (VE)-cadherin homophilic adhesion controls endothelial barrier permeability through assembly of adherens junctions (AJs). We observed that loss of VE-cadherin-mediated adhesion induced the activation of Src and phospholipase C (PLC)γ2, which mediated Ca(2+) release from endoplasmic reticulum (ER) stores, resulting in activation of calcineurin (CaN), a Ca(2+)-dependent phosphatase. Downregulation of CaN activity induced phosphorylation of serine 162 in end binding (EB) protein 3. This phospho-switch was required to destabilize the EB3 dimer, suppress microtubule (MT) growth, and assemble AJs. The phospho-defective S162A EB3 mutant, in contrast, induced MT growth in confluent endothelial monolayers and disassembled AJs. Thus, VE-cadherin outside-in signaling regulates cytosolic Ca(2+) homeostasis and EB3 phosphorylation, which are required for assembly of AJs. These results identify a pivotal function of VE-cadherin homophilic interaction in modulating endothelial barrier through the tuning of MT dynamics."xsd:string |
| http://purl.uniprot.org/citations/23159740 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2012.10.011"xsd:string |
| http://purl.uniprot.org/citations/23159740 | http://purl.uniprot.org/core/author | "Geyer M."xsd:string |
| http://purl.uniprot.org/citations/23159740 | http://purl.uniprot.org/core/author | "Huang F."xsd:string |
| http://purl.uniprot.org/citations/23159740 | http://purl.uniprot.org/core/author | "Garcia A."xsd:string |
| http://purl.uniprot.org/citations/23159740 | http://purl.uniprot.org/core/author | "Malik A.B."xsd:string |
| http://purl.uniprot.org/citations/23159740 | http://purl.uniprot.org/core/author | "Mehta D."xsd:string |
| http://purl.uniprot.org/citations/23159740 | http://purl.uniprot.org/core/author | "Kreutz B."xsd:string |
| http://purl.uniprot.org/citations/23159740 | http://purl.uniprot.org/core/author | "Komarova Y.A."xsd:string |
| http://purl.uniprot.org/citations/23159740 | http://purl.uniprot.org/core/author | "Daneshjou N."xsd:string |
| http://purl.uniprot.org/citations/23159740 | http://purl.uniprot.org/core/author | "Idalino L."xsd:string |
| http://purl.uniprot.org/citations/23159740 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23159740 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/23159740 | http://purl.uniprot.org/core/pages | "914-925"xsd:string |
| http://purl.uniprot.org/citations/23159740 | http://purl.uniprot.org/core/title | "VE-cadherin signaling induces EB3 phosphorylation to suppress microtubule growth and assemble adherens junctions."xsd:string |
| http://purl.uniprot.org/citations/23159740 | http://purl.uniprot.org/core/volume | "48"xsd:string |
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