| http://purl.uniprot.org/citations/23160044 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23160044 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23160044 | http://www.w3.org/2000/01/rdf-schema#comment | "During neurogenesis, neural stem/progenitor cells (NPCs) undergo an irreversible fate transition to become neurons. The Notch pathway is important for this process, and repression of Notch-dependent Hes genes is essential for triggering differentiation. However, Notch signaling often remains active throughout neuronal differentiation, implying a change in the transcriptional responsiveness to Notch during the neurogenic transition. We identified Bcl6, an oncogene, as encoding a proneurogenic factor that is required for proper neurogenesis of the mouse cerebral cortex. BCL6 promoted the neurogenic conversion by switching the composition of Notch-dependent transcriptional complexes at the Hes5 promoter. BCL6 triggered exclusion of the co-activator Mastermind-like 1 and recruitment of the NAD(+)-dependent deacetylase Sirt1, which was required for BCL6-dependent neurogenesis. The resulting epigenetic silencing of Hes5 led to neuronal differentiation despite active Notch signaling. Our findings suggest a role for BCL6 in neurogenesis and uncover Notch-BCL6-Sirt1 interactions that may affect other aspects of physiology and disease."xsd:string |
| http://purl.uniprot.org/citations/23160044 | http://purl.org/dc/terms/identifier | "doi:10.1038/nn.3264"xsd:string |
| http://purl.uniprot.org/citations/23160044 | http://purl.org/dc/terms/identifier | "doi:10.1038/nn.3264"xsd:string |
| http://purl.uniprot.org/citations/23160044 | http://purl.uniprot.org/core/author | "Bouschet T."xsd:string |
| http://purl.uniprot.org/citations/23160044 | http://purl.uniprot.org/core/author | "Bouschet T."xsd:string |
| http://purl.uniprot.org/citations/23160044 | http://purl.uniprot.org/core/author | "Kyba M."xsd:string |
| http://purl.uniprot.org/citations/23160044 | http://purl.uniprot.org/core/author | "Kyba M."xsd:string |
| http://purl.uniprot.org/citations/23160044 | http://purl.uniprot.org/core/author | "Bilheu A."xsd:string |
| http://purl.uniprot.org/citations/23160044 | http://purl.uniprot.org/core/author | "Bilheu A."xsd:string |
| http://purl.uniprot.org/citations/23160044 | http://purl.uniprot.org/core/author | "Bonnefont J."xsd:string |
| http://purl.uniprot.org/citations/23160044 | http://purl.uniprot.org/core/author | "Bonnefont J."xsd:string |
| http://purl.uniprot.org/citations/23160044 | http://purl.uniprot.org/core/author | "Dimidschstein J."xsd:string |
| http://purl.uniprot.org/citations/23160044 | http://purl.uniprot.org/core/author | "Dimidschstein J."xsd:string |
| http://purl.uniprot.org/citations/23160044 | http://purl.uniprot.org/core/author | "Gall D."xsd:string |
| http://purl.uniprot.org/citations/23160044 | http://purl.uniprot.org/core/author | "Gall D."xsd:string |
| http://purl.uniprot.org/citations/23160044 | http://purl.uniprot.org/core/author | "Herpoel A."xsd:string |
| http://purl.uniprot.org/citations/23160044 | http://purl.uniprot.org/core/author | "Herpoel A."xsd:string |
| http://purl.uniprot.org/citations/23160044 | http://purl.uniprot.org/core/author | "Iacovino M."xsd:string |
| http://purl.uniprot.org/citations/23160044 | http://purl.uniprot.org/core/author | "Iacovino M."xsd:string |
| http://purl.uniprot.org/citations/23160044 | http://purl.uniprot.org/core/author | "Piccirilli J."xsd:string |
| http://purl.uniprot.org/citations/23160044 | http://purl.uniprot.org/core/author | "Piccirilli J."xsd:string |
| http://purl.uniprot.org/citations/23160044 | http://purl.uniprot.org/core/author | "Tiberi L."xsd:string |
| http://purl.uniprot.org/citations/23160044 | http://purl.uniprot.org/core/author | "Tiberi L."xsd:string |