| http://purl.uniprot.org/citations/23160154 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23160154 | http://www.w3.org/2000/01/rdf-schema#comment | "The sensing of viral nucleic acids by the innate immune system triggers the production of type I interferons, which activates interferon-stimulated genes (ISGs) and directs a multifaceted antiviral response. ISGs can also be activated through interferon-independent pathways, although the precise mechanisms remain elusive. Here we found that the cytosolic exonuclease Trex1 regulated the activation of a subset of ISGs independently of interferon. Both Trex1(-/-) mouse cells and Trex1-mutant human cells had high expression of genes encoding antiviral molecules ('antiviral genes') and were refractory to viral infection. The interferon-independent activation of antiviral genes in Trex1(-/-) cells required the adaptor STING, the kinase TBK1 and the transcription factors IRF3 and IRF7. We also found that Trex1-deficient cells had an expanded lysosomal compartment, altered subcellular localization of the transcription factor TFEB and diminished activity of the regulator mTORC1. Together our data identify Trex1 as a regulator of lysosomal biogenesis and interferon-independent activation of antiviral genes and show that dysregulation of lysosomes can elicit innate immune responses."xsd:string |
| http://purl.uniprot.org/citations/23160154 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.2475"xsd:string |
| http://purl.uniprot.org/citations/23160154 | http://purl.uniprot.org/core/author | "Koch J."xsd:string |
| http://purl.uniprot.org/citations/23160154 | http://purl.uniprot.org/core/author | "Levine B."xsd:string |
| http://purl.uniprot.org/citations/23160154 | http://purl.uniprot.org/core/author | "Hasan M."xsd:string |
| http://purl.uniprot.org/citations/23160154 | http://purl.uniprot.org/core/author | "Pattnaik A.K."xsd:string |
| http://purl.uniprot.org/citations/23160154 | http://purl.uniprot.org/core/author | "Yan N."xsd:string |
| http://purl.uniprot.org/citations/23160154 | http://purl.uniprot.org/core/author | "Wakeland E.K."xsd:string |
| http://purl.uniprot.org/citations/23160154 | http://purl.uniprot.org/core/author | "Rakheja D."xsd:string |
| http://purl.uniprot.org/citations/23160154 | http://purl.uniprot.org/core/author | "Brugarolas J."xsd:string |
| http://purl.uniprot.org/citations/23160154 | http://purl.uniprot.org/core/author | "Dozmorov I."xsd:string |
| http://purl.uniprot.org/citations/23160154 | http://purl.uniprot.org/core/author | "Lee-Kirsch M.A."xsd:string |
| http://purl.uniprot.org/citations/23160154 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23160154 | http://purl.uniprot.org/core/name | "Nat Immunol"xsd:string |
| http://purl.uniprot.org/citations/23160154 | http://purl.uniprot.org/core/pages | "61-71"xsd:string |
| http://purl.uniprot.org/citations/23160154 | http://purl.uniprot.org/core/title | "Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes."xsd:string |
| http://purl.uniprot.org/citations/23160154 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/23160154 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23160154 |
| http://purl.uniprot.org/citations/23160154 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23160154 |
| http://purl.uniprot.org/uniprot/P70671#attribution-F5EB4E28E97B5FFD05EE15C0EC4C757C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23160154 |
| http://purl.uniprot.org/uniprot/P70434#attribution-F5EB4E28E97B5FFD05EE15C0EC4C757C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23160154 |
| http://purl.uniprot.org/uniprot/Q3TBT3#attribution-F5EB4E28E97B5FFD05EE15C0EC4C757C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23160154 |
| http://purl.uniprot.org/uniprot/Q9WUN2#attribution-F5EB4E28E97B5FFD05EE15C0EC4C757C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23160154 |
| http://purl.uniprot.org/uniprot/Q91XB0#attribution-9748FB7C5322AD1EDD6BC168DBF6BB56 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23160154 |