| http://purl.uniprot.org/citations/23160180 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23160180 | http://www.w3.org/2000/01/rdf-schema#comment | "Delta-5 and delta-6 desaturases (D5D and D6D) are key enzymes in endogenous synthesis of long-chain PUFAs. In this sample of healthy subjects (n = 310), genotypes of single nucleotide polymorphisms (SNPs) rs174537, rs174561, and rs3834458 in the FADS1-FADS2 gene cluster were strongly associated with proportions of LC-PUFAs and desaturase activities estimated in plasma and erythrocytes. Minor allele carriage associated with decreased activities of D5D (FADS1) (5.84 × 10(-19) ≤ P ≤ 4.5 × 10(-18)) and D6D (FADS2) (6.05 × 10(-8) ≤ P ≤ 4.20 × 10(-7)) was accompanied by increased substrate and decreased product proportions (0.05 ≤ P ≤ 2.49 × 10(-16)). The significance of haplotype association with D5D activity (P = 2.19 × 10(-17)) was comparable to that of single SNPs, but haplotype association with D6D activity (P = 3.39 × 10(-28)) was much stronger. In a randomized controlled dietary intervention, increasing eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3) intake significantly increased D5D (P = 4.0 × 10(-9)) and decreased D6D activity (P = 9.16 × 10(-6)) after doses of 0.45, 0.9, and 1.8 g/day for six months. Interaction of rs174537 genotype with treatment was a determinant of D5D activity estimated in plasma (P = 0.05). In conclusion, different sites at the FADS1-FADS2 locus appear to influence D5D and D6D activity, and rs174537 genotype interacts with dietary EPA+DHA to modulate D5D."xsd:string |
| http://purl.uniprot.org/citations/23160180 | http://purl.org/dc/terms/identifier | "doi:10.1194/jlr.p032276"xsd:string |
| http://purl.uniprot.org/citations/23160180 | http://purl.uniprot.org/core/author | "Sanders T.A."xsd:string |
| http://purl.uniprot.org/citations/23160180 | http://purl.uniprot.org/core/author | "O'Dell S.D."xsd:string |
| http://purl.uniprot.org/citations/23160180 | http://purl.uniprot.org/core/author | "Maniou Z."xsd:string |
| http://purl.uniprot.org/citations/23160180 | http://purl.uniprot.org/core/author | "Alsaleh A."xsd:string |
| http://purl.uniprot.org/citations/23160180 | http://purl.uniprot.org/core/author | "Hall W.L."xsd:string |
| http://purl.uniprot.org/citations/23160180 | http://purl.uniprot.org/core/author | "Al-Hilal M."xsd:string |
| http://purl.uniprot.org/citations/23160180 | http://purl.uniprot.org/core/author | "Lewis F.J."xsd:string |
| http://purl.uniprot.org/citations/23160180 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23160180 | http://purl.uniprot.org/core/name | "J Lipid Res"xsd:string |
| http://purl.uniprot.org/citations/23160180 | http://purl.uniprot.org/core/pages | "542-551"xsd:string |
| http://purl.uniprot.org/citations/23160180 | http://purl.uniprot.org/core/title | "Genetic variation at the FADS1-FADS2 gene locus influences delta-5 desaturase activity and LC-PUFA proportions after fish oil supplement."xsd:string |
| http://purl.uniprot.org/citations/23160180 | http://purl.uniprot.org/core/volume | "54"xsd:string |
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