| http://purl.uniprot.org/citations/23160462 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23160462 | http://www.w3.org/2000/01/rdf-schema#comment | "The inv(16)(p13q22)/t(16;16)(p13;q22) in acute myeloid leukemia results in multiple CBFB-MYH11 fusion transcripts, with type A being most frequent. The biologic and prognostic implications of different fusions are unclear. We analyzed CBFB-MYH11 fusion types in 208 inv(16)/t(16;16) patients with de novo disease, and compared clinical and cytogenetic features and the KIT mutation status between type A (n = 182; 87%) and non-type A (n = 26; 13%) patients. At diagnosis, non-type A patients had lower white blood counts (P = .007), and more often trisomies of chromosomes 8 (P = .01) and 21 (P < .001) and less often trisomy 22 (P = .02). No patient with non-type A fusion carried a KIT mutation, whereas 27% of type A patients did (P = .002). Among the latter, KIT mutations conferred adverse prognosis; clinical outcomes of non-type A and type A patients with wild-type KIT were similar. We also derived a fusion-type-associated global gene-expression profile. Gene Ontology analysis of the differentially expressed genes revealed-among others-an enrichment of up-regulated genes involved in activation of caspase activity, cell differentiation and cell cycle control in non-type A patients. We conclude that non-type A fusions associate with distinct clinical and genetic features, including lack of KIT mutations, and a unique gene-expression profile."xsd:string |
| http://purl.uniprot.org/citations/23160462 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2012-07-442772"xsd:string |
| http://purl.uniprot.org/citations/23160462 | http://purl.uniprot.org/core/author | "Volinia S."xsd:string |
| http://purl.uniprot.org/citations/23160462 | http://purl.uniprot.org/core/author | "Crawford J."xsd:string |
| http://purl.uniprot.org/citations/23160462 | http://purl.uniprot.org/core/author | "Goodman B.K."xsd:string |
| http://purl.uniprot.org/citations/23160462 | http://purl.uniprot.org/core/author | "Ning Y."xsd:string |
| http://purl.uniprot.org/citations/23160462 | http://purl.uniprot.org/core/author | "Leonard J."xsd:string |
| http://purl.uniprot.org/citations/23160462 | http://purl.uniprot.org/core/author | "Le Beau M.M."xsd:string |
| http://purl.uniprot.org/citations/23160462 | http://purl.uniprot.org/core/author | "Kulkarni S."xsd:string |
| http://purl.uniprot.org/citations/23160462 | http://purl.uniprot.org/core/author | "Mohandas T.K."xsd:string |
| http://purl.uniprot.org/citations/23160462 | http://purl.uniprot.org/core/author | "Hurd D.D."xsd:string |
| http://purl.uniprot.org/citations/23160462 | http://purl.uniprot.org/core/author | "Bloomfield C.D."xsd:string |
| http://purl.uniprot.org/citations/23160462 | http://purl.uniprot.org/core/author | "Caligiuri M.A."xsd:string |
| http://purl.uniprot.org/citations/23160462 | http://purl.uniprot.org/core/author | "Blum W."xsd:string |
| http://purl.uniprot.org/citations/23160462 | http://purl.uniprot.org/core/author | "Dal Cin P."xsd:string |
| http://purl.uniprot.org/citations/23160462 | http://purl.uniprot.org/core/author | "Bader P.I."xsd:string |
| http://purl.uniprot.org/citations/23160462 | http://purl.uniprot.org/core/author | "Kolitz J.E."xsd:string |
| http://purl.uniprot.org/citations/23160462 | http://purl.uniprot.org/core/author | "Mrozek K."xsd:string |
| http://purl.uniprot.org/citations/23160462 | http://purl.uniprot.org/core/author | "Wu Y.Z."xsd:string |
| http://purl.uniprot.org/citations/23160462 | http://purl.uniprot.org/core/author | "Becker H."xsd:string |
| http://purl.uniprot.org/citations/23160462 | http://purl.uniprot.org/core/author | "Miron P."xsd:string |
| http://purl.uniprot.org/citations/23160462 | http://purl.uniprot.org/core/author | "Mathew S."xsd:string |
| http://purl.uniprot.org/citations/23160462 | http://purl.uniprot.org/core/author | "Lindgren V."xsd:string |
| http://purl.uniprot.org/citations/23160462 | http://purl.uniprot.org/core/author | "Pettenati M.J."xsd:string |