| http://purl.uniprot.org/citations/23160529 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23160529 | http://www.w3.org/2000/01/rdf-schema#comment | "We investigated whether HLA-A*24 typing complements screening for HLA-DQ and for antibodies (Abs) against insulin, GAD, IA-2 (IA-2A), and zinc transporter-8 (ZnT8A) for prediction of rapid progression to type 1 diabetes (T1D). Persistently Ab(+) siblings/offspring (n = 288; aged 0-39 years) of T1D patients were genotyped for HLA-DQA1-DQB1 and HLA-A*24 and monitored for development of diabetes within 5 years of first Ab(+). HLA-A*24 (P = 0.009), HLA-DQ2/DQ8 (P = 0.001), and positivity for IA-2A ± ZnT8A (P < 0.001) were associated with development of T1D in multivariate analysis. The 5-year risk increased with the number of the above three markers present (n = 0: 6%; n = 1: 18%; n = 2: 46%; n = 3: 100%). Positivity for one or more markers identified a subgroup of 171 (59%) containing 88% of rapid progressors. The combined presence of HLA-A*24 and IA-2A(+) ± ZnT8A(+) defined a subgroup of 18 (6%) with an 82% diabetes risk. Among IA-2A(+) ± ZnT8A(+) relatives, identification of HLA-A*24 carriers in addition to HLA-DQ2/DQ8 carriers increased screening sensitivity for relatives at high Ab- and HLA-inferred risk (64% progression; P = 0.002). In conclusion, HLA-A*24 independently predicts rapid progression to T1D in Ab(+) relatives and complements IA-2A, ZnT8A, and HLA-DQ2/DQ8 for identifying participants in immunointervention trials."xsd:string |
| http://purl.uniprot.org/citations/23160529 | http://purl.org/dc/terms/identifier | "doi:10.2337/db12-0747"xsd:string |
| http://purl.uniprot.org/citations/23160529 | http://purl.uniprot.org/core/author | "Van Aken S."xsd:string |
| http://purl.uniprot.org/citations/23160529 | http://purl.uniprot.org/core/author | "Weber E."xsd:string |
| http://purl.uniprot.org/citations/23160529 | http://purl.uniprot.org/core/author | "Ivens A."xsd:string |
| http://purl.uniprot.org/citations/23160529 | http://purl.uniprot.org/core/author | "Vanneste S."xsd:string |
| http://purl.uniprot.org/citations/23160529 | http://purl.uniprot.org/core/author | "Carlier A."xsd:string |
| http://purl.uniprot.org/citations/23160529 | http://purl.uniprot.org/core/author | "Marchal M."xsd:string |
| http://purl.uniprot.org/citations/23160529 | http://purl.uniprot.org/core/author | "Pipeleers D."xsd:string |
| http://purl.uniprot.org/citations/23160529 | http://purl.uniprot.org/core/author | "Haemers A."xsd:string |
| http://purl.uniprot.org/citations/23160529 | http://purl.uniprot.org/core/author | "Van Poucke K."xsd:string |
| http://purl.uniprot.org/citations/23160529 | http://purl.uniprot.org/core/author | "Van Helvoirt M."xsd:string |
| http://purl.uniprot.org/citations/23160529 | http://purl.uniprot.org/core/author | "Mathieu C."xsd:string |
| http://purl.uniprot.org/citations/23160529 | http://purl.uniprot.org/core/author | "Bachy A."xsd:string |
| http://purl.uniprot.org/citations/23160529 | http://purl.uniprot.org/core/author | "Massa G."xsd:string |
| http://purl.uniprot.org/citations/23160529 | http://purl.uniprot.org/core/author | "Wenzlau J.M."xsd:string |
| http://purl.uniprot.org/citations/23160529 | http://purl.uniprot.org/core/author | "Hutton J.C."xsd:string |
| http://purl.uniprot.org/citations/23160529 | http://purl.uniprot.org/core/author | "Bex M."xsd:string |
| http://purl.uniprot.org/citations/23160529 | http://purl.uniprot.org/core/author | "Van der Schueren B."xsd:string |
| http://purl.uniprot.org/citations/23160529 | http://purl.uniprot.org/core/author | "Bataille G."xsd:string |
| http://purl.uniprot.org/citations/23160529 | http://purl.uniprot.org/core/author | "Renneboog B."xsd:string |
| http://purl.uniprot.org/citations/23160529 | http://purl.uniprot.org/core/author | "Vanderstraeten S."xsd:string |
| http://purl.uniprot.org/citations/23160529 | http://purl.uniprot.org/core/author | "Cnop M."xsd:string |
| http://purl.uniprot.org/citations/23160529 | http://purl.uniprot.org/core/author | "Claessens A."xsd:string |