| http://purl.uniprot.org/citations/23166633 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23166633 | http://www.w3.org/2000/01/rdf-schema#comment | "p53 is a tumor suppressor gene mutated in >50% of human cancers, while p53 deficiency in mice results in cancers and accelerated mortality. Thymic T cell lymphoma is the most common malignancy in p53-deficient mice, making it difficult to study the role of p53 in other malignancies. To overcome this limitation, we attempted to generate mice with a reversible p53 knockout (p53(rev/rev)) by inserting a floxed transcriptional stop into the first exon of p53, anticipating that this would allow tissue-specific Cre-mediated expression of p53. Contrary to expectations, functional p53 protein was expressed in the thymus and multiple other tissues of p53(rev/rev) mice in the absence of Cre, whereas B cells expressed p53 protein only in the presence of B cell-specific CD19-Cre. In the absence of Cre, 76% of p53(rev/rev) mice developed splenic marginal zone B cell lymphomas, indicating sensitivity of this B cell subset to transformation caused by p53 deficiency. 5'-RACE identified p53 mRNA transcribed from a novel start site utilized in thymocytes but not normal B cells or B cell lymphomas from p53(rev/rev) mice. The p53(rev/rev) mouse thus demonstrates an effect of p53 deficiency in development of splenic marginal zone lymphomas and provides a model for study of p53-deficient human B cell lymphomas."xsd:string |
| http://purl.uniprot.org/citations/23166633 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0049305"xsd:string |
| http://purl.uniprot.org/citations/23166633 | http://purl.uniprot.org/core/author | "Tessarollo L."xsd:string |
| http://purl.uniprot.org/citations/23166633 | http://purl.uniprot.org/core/author | "Chiang Y.J."xsd:string |
| http://purl.uniprot.org/citations/23166633 | http://purl.uniprot.org/core/author | "Hodes R.J."xsd:string |
| http://purl.uniprot.org/citations/23166633 | http://purl.uniprot.org/core/author | "Difilippantonio M.J."xsd:string |
| http://purl.uniprot.org/citations/23166633 | http://purl.uniprot.org/core/author | "Morse H.C."xsd:string |
| http://purl.uniprot.org/citations/23166633 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23166633 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/23166633 | http://purl.uniprot.org/core/pages | "e49305"xsd:string |
| http://purl.uniprot.org/citations/23166633 | http://purl.uniprot.org/core/title | "Exon 1 disruption alters tissue-specific expression of mouse p53 and results in selective development of B cell lymphomas."xsd:string |
| http://purl.uniprot.org/citations/23166633 | http://purl.uniprot.org/core/volume | "7"xsd:string |
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