| http://purl.uniprot.org/citations/23172129 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23172129 | http://www.w3.org/2000/01/rdf-schema#comment | "Nuclear factor of activated T cells 5 (NFAT5) has been implicated in regulating several genes that are thought to be neuroprotective in ischemic injury. Because of the embryonic lethality of NFAT5 knockout (NFAT5(-/-)) mice, the heterozygous (NFAT5(+/-)) mice were used to study the in vivo role of NFAT5 in hypoxia/ischemia (H/I) condition. The NFAT5(+/-) mice exhibited more severe neurological deficits, larger infarct area and edema formation associated with increased aquaporin 4 expressions in the brain. Under in vitro H/I condition, increased apoptotic cell death was found in NFAT5(-/-) neurons. Moreover, SMIT, a downstream to NFAT5, was upregulated in NFAT5(+/+) neurons, while the SMIT level could not be upregulated in NFAT5(-/-) neurons under H/I condition. The elevation of reactive oxygen species generation in NFAT5(-/-) neurons under H/I condition further confirmed that NFAT5(-/-) neurons were more susceptible to oxidative stress. The present study demonstrated that activation of NFAT5 and its downstream SMIT induction is important in protecting neurons from ischemia-induced oxidative stress."xsd:string |
| http://purl.uniprot.org/citations/23172129 | http://purl.org/dc/terms/identifier | "doi:10.1159/000331899"xsd:string |
| http://purl.uniprot.org/citations/23172129 | http://purl.uniprot.org/core/author | "Chung S.S."xsd:string |
| http://purl.uniprot.org/citations/23172129 | http://purl.uniprot.org/core/author | "Chung S.K."xsd:string |
| http://purl.uniprot.org/citations/23172129 | http://purl.uniprot.org/core/author | "Ko B.C."xsd:string |
| http://purl.uniprot.org/citations/23172129 | http://purl.uniprot.org/core/author | "Lam A.K."xsd:string |
| http://purl.uniprot.org/citations/23172129 | http://purl.uniprot.org/core/author | "Yeung P.K."xsd:string |
| http://purl.uniprot.org/citations/23172129 | http://purl.uniprot.org/core/author | "Lo A.C."xsd:string |
| http://purl.uniprot.org/citations/23172129 | http://purl.uniprot.org/core/author | "Mak K.M."xsd:string |
| http://purl.uniprot.org/citations/23172129 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23172129 | http://purl.uniprot.org/core/name | "Neurosignals"xsd:string |
| http://purl.uniprot.org/citations/23172129 | http://purl.uniprot.org/core/pages | "237-251"xsd:string |
| http://purl.uniprot.org/citations/23172129 | http://purl.uniprot.org/core/title | "Nuclear factor of activated T cells 5 deficiency increases the severity of neuronal cell death in ischemic injury."xsd:string |
| http://purl.uniprot.org/citations/23172129 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/23172129 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23172129 |
| http://purl.uniprot.org/citations/23172129 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23172129 |
| http://purl.uniprot.org/uniprot/#_A0A1U6URG8-mappedCitation-23172129 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23172129 |
| http://purl.uniprot.org/uniprot/#_D6RH40-mappedCitation-23172129 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23172129 |
| http://purl.uniprot.org/uniprot/#_F6VCW7-mappedCitation-23172129 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23172129 |
| http://purl.uniprot.org/uniprot/#_F6ZRF0-mappedCitation-23172129 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23172129 |
| http://purl.uniprot.org/uniprot/#_Q3UZU9-mappedCitation-23172129 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23172129 |
| http://purl.uniprot.org/uniprot/#_Q3UZ77-mappedCitation-23172129 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23172129 |
| http://purl.uniprot.org/uniprot/#_Q3UMR9-mappedCitation-23172129 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23172129 |
| http://purl.uniprot.org/uniprot/#_Q3UW17-mappedCitation-23172129 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23172129 |